PMID- 17256161
OWN - NLM
STAT- MEDLINE
DCOM- 20080404
LR  - 20220716
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 180
IP  - 2
DP  - 2007 Jun
TI  - Spontaneous low threshold spike bursting in awake humans is different in 
      different lateral thalamic nuclei.
PG  - 281-8
AB  - Spontaneous action potential bursts associated with low threshold calcium spikes 
      (LTS) occur in multiple human lateral thalamic nuclei, each with different 
      physiologic characteristics. We now test the hypothesis that different patterns 
      of spontaneous LTS bursting occur in these nuclei during awake surgery in 
      patients with essential tremor and the arm at rest. This protocol was chosen to 
      minimize the effect of the patient's disease upon thalamic activity which is a 
      potential confound in a surgical study of this type. Neuronal activity was 
      studied in the human thalamic nuclei receiving somatic sensory input (Vc, ventral 
      caudal), input from the deep cerebellar nuclei (Vim, ventral intermediate), or 
      input from the pallidum (Vo, ventral oral). In each nucleus the burst rates were 
      significantly greater than zero. Burst rates were higher in Vc than in Vim, while 
      firing rates were lower. These findings suggest that neurons in Vc are 
      hyperpolarized and have more frequent inhibitory events. Pre-burst inter-spike 
      intervals (ISIs) were significantly longer in Vc, but were significantly shorter 
      when corrected for the average ISIs between bursts (burst rate/inverse of the 
      primary event rate). These results suggest that inhibitory events in Vc are of 
      lower magnitude relative to a hyperpolarized resting membrane potential. Studies 
      in many species demonstrate that input from the pallidum to the thalamus is 
      inhibitory, suggesting that input to Vo is predominantly inhibitory. However, 
      neurons in Vo have neither slower firing rates nor more frequent LTS bursts. 
      Previous studies have found that spontaneous LTS is similar between classes of 
      neurons within Vc, as defined by their response to thermal and painful stimuli. 
      The differences in spontaneous LTS between human nuclei but not between 
      functional classes within a nucleus may be a basic organizing principle of 
      thalamic inhibitory circuitry.
FAU - Ohara, S
AU  - Ohara S
AD  - Department of Neurosurgery, Meyer Building 7-113, Johns Hopkins Hospital, 600 
      North Wolfe Street, Baltimore, MD 21287-7713, USA.
FAU - Taghva, A
AU  - Taghva A
FAU - Kim, J H
AU  - Kim JH
FAU - Lenz, F A
AU  - Lenz FA
LA  - eng
GR  - NS 383493/NS/NINDS NIH HHS/United States
GR  - NS 40059/NS/NINDS NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070126
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
SB  - IM
MH  - Action Potentials/*physiology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Deep Brain Stimulation/methods
MH  - Essential Tremor/*physiopathology/therapy
MH  - Female
MH  - Humans
MH  - Lateral Thalamic Nuclei/*physiopathology/radiation effects
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sensory Thresholds/*physiology/radiation effects
MH  - *Wakefulness
EDAT- 2007/01/27 09:00
MHDA- 2008/04/05 09:00
CRDT- 2007/01/27 09:00
PHST- 2006/10/22 00:00 [received]
PHST- 2007/01/03 00:00 [accepted]
PHST- 2007/01/27 09:00 [pubmed]
PHST- 2008/04/05 09:00 [medline]
PHST- 2007/01/27 09:00 [entrez]
AID - 10.1007/s00221-007-0856-9 [doi]
PST - ppublish
SO  - Exp Brain Res. 2007 Jun;180(2):281-8. doi: 10.1007/s00221-007-0856-9. Epub 2007 
      Jan 26.