PMID- 17256361
OWN - NLM
STAT- MEDLINE
DCOM- 20070222
LR  - 20190715
IS  - 1533-4880 (Print)
IS  - 1533-4880 (Linking)
VI  - 6
IP  - 12
DP  - 2006 Dec
TI  - Supramolecular assembled nanostructure containing cubic silsesquioxane in aqueous 
      solution.
PG  - 3955-9
AB  - Micellization and aggregation behavior of amphiphilic cubic 
      silsesquioxane-poly(ethylene oxide) (CSSQ-PEO) in aqueous solution was studied by 
      Dynamic and Static Light Scattering (DLS and SLS), and Transmission Electron 
      Microscopy (TEM). The effects of CSSQ-PEO concentration and temperature on 
      particle size were also investigated. Above the critical aggregation 
      concentration (CAC), a combination of unassociated single micelle and micellar 
      aggregates is observed up to a certain level of CSSQ-PEO concentration as 
      determined by DLS and TEM studies. The size of unassociated single micelles are 
      found to be independent of CSSQ-PEO concentration while that of the micellar 
      aggregates become larger at higher concentration due to the aggregation growth. 
      Both studies revealed that a small CSSQ core is surrounded by PEO corona and 
      found self-assembled nanostructure of CSSQ-PEO in aqueous solution. The molecular 
      weight of micellar aggregates (Mw,agg), radius of gyration (Rg), and apparent 
      aggregation number (Nagg) were evaluated by SLS measurement. The decrease in the 
      particle size (described by hydrodynamic diameter: Dh) upon increasing 
      temperature was observed because of the diminishing hydrophilicity of PEO. 
      Surprisingly, Rg is also decreased at higher temperature assuming the 
      dissociation of micellar aggregates by repulsive forces due to the crowding 
      effect. The encapsulation property of CSSQ-PEO to model drug has also been 
      studied. Our preliminary results from DLS and TEM studies showed the formation of 
      CSSQ-PEO nanospheres containing drug in aqueous solution. The size of the drug 
      loaded CSSQ-PEO nanospheres are found to be larger (250-300 nm) than that of the 
      core-corona CSSQ-PEO micellar aggregates (approximatly 180 nm) in dilute aqueous 
      solution.
FAU - Mya, Khine Yi
AU  - Mya KY
AD  - Institute of Materials Research and Engineering, 3 Research Link, Singapore 
      117602.
FAU - Li, Xu
AU  - Li X
FAU - Chen, Ling
AU  - Chen L
FAU - He, Chaobin
AU  - He C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nanosci Nanotechnol
JT  - Journal of nanoscience and nanotechnology
JID - 101088195
RN  - 0 (Macromolecular Substances)
RN  - 0 (Organosilicon Compounds)
SB  - IM
MH  - Crystallization/*methods
MH  - Macromolecular Substances/*chemistry
MH  - Materials Testing
MH  - Molecular Conformation
MH  - Nanostructures/*chemistry/*ultrastructure
MH  - Nanotechnology/*methods
MH  - Organosilicon Compounds/*chemistry
MH  - Particle Size
MH  - Surface Properties
EDAT- 2007/01/30 09:00
MHDA- 2007/02/23 09:00
CRDT- 2007/01/30 09:00
PHST- 2007/01/30 09:00 [pubmed]
PHST- 2007/02/23 09:00 [medline]
PHST- 2007/01/30 09:00 [entrez]
AID - 10.1166/jnn.2006.661 [doi]
PST - ppublish
SO  - J Nanosci Nanotechnol. 2006 Dec;6(12):3955-9. doi: 10.1166/jnn.2006.661.