PMID- 17257316
OWN - NLM
STAT- MEDLINE
DCOM- 20070516
LR  - 20231213
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69
IP  - 2
DP  - 2007 Feb
TI  - HLA-E*0101 and HLA-G*010101 reduce the risk of Behcet's disease.
PG  - 139-44
AB  - The nonclassical human leukocyte antigen (HLA)-E and -G molecules have previously 
      been shown to inhibit natural killer- and cytotoxic T-lymphocyte-mediated cell 
      lysis and have also been shown to prevent the proliferation of CD4 T cells and 
      secrete cytokines that appear to be important in the modulation of the Behcet's 
      disease (BD) immune systems. Polymorphisms in the HLA-E and HLA-G genes have been 
      associated with differential expression and function. Thus, we conducted an 
      analysis of the HLA-E and HLA-G alleles using Amplification Refractory Mutation 
      System-polymerase chain reaction (PCR) and PCR-restriction fragment length 
      polymorphism techniques in a study comprising 312 patients with BD and 486 
      controls. The HLA-E*0101 and HLA-G*010101 alleles were associated with a reduced 
      risk of BD (P = 0.0002, odds ratio (OR) = 0.7 and P = 0.002, OR = 0.7, 
      respectively). By way of contrast, the variants HLA-E*010302, HLA-G*010102, 
      G*0105N alleles and 3741_3754ins14bp were all associated with an increased risk 
      of BD (P < 0.0001, OR = 1.6; P = 0.002, OR = 1.8; P = 0.024, OR = 2.0 and P = 
      0.003, OR = 1.4, respectively). Individuals carrying both the HLA-E*0101 and the 
      HLA-G*010101 alleles evidenced significantly lower frequency in the patients than 
      in the controls (35.6% vs 49.6%; P < 0.0001, OR = 0.6). These results indicate 
      that variant HLA-E and HLA-G molecules appear to function independently and 
      synergistically, increasing the risk of BD, and may result in an imbalance of 
      lymphocytic functions, which may culminate in the development of BD.
FAU - Park, K S
AU  - Park KS
AD  - Department of Biology, Sungshin Women's University, Seoul, South Korea. 
      kspark@sungshin.ac.kr
FAU - Park, J S
AU  - Park JS
FAU - Nam, J H
AU  - Nam JH
FAU - Bang, D
AU  - Bang D
FAU - Sohn, S
AU  - Sohn S
FAU - Lee, E S
AU  - Lee ES
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (HLA-G*01:01:01 antigen)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alleles
MH  - Behcet Syndrome/*genetics/immunology
MH  - Gene Frequency
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I
MH  - Humans
MH  - Lymphocytes/immunology
MH  - *Polymorphism, Genetic
MH  - Risk
MH  - HLA-E Antigens
EDAT- 2007/01/30 09:00
MHDA- 2007/05/17 09:00
CRDT- 2007/01/30 09:00
PHST- 2007/01/30 09:00 [pubmed]
PHST- 2007/05/17 09:00 [medline]
PHST- 2007/01/30 09:00 [entrez]
AID - TAN742 [pii]
AID - 10.1111/j.1399-0039.2006.00742.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Feb;69(2):139-44. doi: 10.1111/j.1399-0039.2006.00742.x.