PMID- 17257320
OWN - NLM
STAT- MEDLINE
DCOM- 20070516
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69
IP  - 2
DP  - 2007 Feb
TI  - Association between hepatitis B virus infection and HLA-DRB1 genotyping in 
      Shaanxi Han patients in northwestern China.
PG  - 170-5
AB  - Hepatitis B virus (HBV) infection is a major public health problem worldwide. The 
      mechanism of susceptibility to chronic persistent HBV infection is not well 
      clarified, while the outcome of HBV infection mainly depends on the host immune 
      response. Human leukocyte antigen (HLA) class II molecule is an integral 
      component of the immune response on which majority of host genetic studies have 
      concentrated. Many different HLA class II alleles have been demonstrated to play 
      roles in HBV infection. In this study, the association between HBV infection and 
      HLA-DRB1 alleles in Han individuals in northwestern China was studied for the 
      first time. Two hundred and fifty Shaanxi Han individuals were categorized into 
      three different groups: the HBV-infected patient group (n = 108), the 
      spontaneously cleared control group (n = 108) and the unexposed group (n = 34). 
      DRB1*04, DRB1*09, DRB1*12 and DRB1*15 were the most common genotypes in all the 
      groups. The allele frequencies of HLA-DRB1*03 [10.6% of HBV-infected patients vs 
      3.7% of spontaneously cleared controls, odds ratios (OR) = 3.10, Pc = 0.008, P < 
      0.05] and HLA-DRB1*07 (17.6% of HBV-infected patients vs 9.3% of spontaneously 
      cleared controls, Pc = 0.016, OR = 2.09, P < 0.05) were markedly higher in the 
      HBV-infected group. But the allele frequencies of HLA-DRB1*15 (6.9% of 
      HBV-infected patients vs 13.4% of spontaneously cleared controls Pc = 0.039, OR = 
      0.48, P < 0.05) were obviously lower than that of the spontaneously cleared 
      controls. The above data indicate that HLA-DRB1*03 and HLA-DRB1*07 are related to 
      susceptibility to chronic HBV infection, and DRB1*15 is negatively related to 
      persistence to chronic HBV infection among people in northwestern China. Similar 
      results were got for DRB1*03 and 15 alleles between the HBV-infected patients (n 
      = 108) and 46 HBV seronegative spouses of the HBV patients, who were high-risk 
      group for HBV infection. The above results suggest that host HLA class II gene is 
      an important factor in determination of the outcome of HBV infection.
FAU - Yang, G
AU  - Yang G
AD  - State Key Laboratory for Cancer Biology, Department of Digestive Diseases, Xijing 
      Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.
FAU - Liu, J
AU  - Liu J
FAU - Han, S
AU  - Han S
FAU - Xie, H
AU  - Xie H
FAU - Du, R
AU  - Du R
FAU - Yan, Y
AU  - Yan Y
FAU - Xu, D
AU  - Xu D
FAU - Fan, D
AU  - Fan D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - China
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Hepatitis B/*genetics
MH  - *Hepatitis B virus
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2007/01/30 09:00
MHDA- 2007/05/17 09:00
CRDT- 2007/01/30 09:00
PHST- 2007/01/30 09:00 [pubmed]
PHST- 2007/05/17 09:00 [medline]
PHST- 2007/01/30 09:00 [entrez]
AID - TAN744 [pii]
AID - 10.1111/j.1399-0039.2006.00744.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Feb;69(2):170-5. doi: 10.1111/j.1399-0039.2006.00744.x.