PMID- 17257493
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20070129
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 3
IP  - 6
DP  - 2006 Dec
TI  - Dendritic cells as a pharmacological target of traditional Chinese medicine.
PG  - 401-10
AB  - Dendritic cells (DCs) represent a heterogeneous population of professional 
      antigen-presenting cells (APCs) that play a central role in the initiation and 
      regulation of immune responses. There is considerable evidence that DCs can be 
      used as therapeutic targets for pharmacological modulation of immune responses. 
      Traditional Chinese medicine (TCM) has a long-standing history of using herbal 
      medicine in the treatment of variety of human diseases. Many of the clinical 
      effects of TCM have reportedly been attributed to the up- or down-regulation of 
      immune responses. Accumulating evidence indicates that TCM and its components can 
      interfere with immune responses at the earliest stage by targeting key functions 
      of DCs. Here, we review those published studies of TCM with respect to their 
      effects on immunobiological functions of DCs. Investigations based on both 
      chemical entities derived from TCM as well as TCM herbal mixtures are presented. 
      These studies suggest that various TCM herbal medicines have the capacity to 
      inhibit or promote major functions of DCs, such as differentiation, maturation, 
      cytokine production, survival, antigen uptake and presentation as well as 
      trafficking. These studies have revealed novel biological effects of TCM and 
      documented the utility of this approach to discover novel biological modifier of 
      DC functions derived from natural sources.
FAU - Chen, Xin
AU  - Chen X
AD  - Basic Research Program, SAIC-Frederick, Inc., Lab of Molecular Immunoregulation, 
      Cancer and Inflammation Program, CCR, NCI-Frederick, P.O. Box B, Bldg 560, Rm 
      31-19, Maryland 21702-1201, USA. chenxin@mail.nih.gov
FAU - Yang, Lu
AU  - Yang L
FAU - Howard, O M Zack
AU  - Howard OM
FAU - Oppenheim, Joost J
AU  - Oppenheim JJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
SB  - IM
MH  - Dendritic Cells/*drug effects/immunology/metabolism
MH  - Humans
MH  - *Medicine, Chinese Traditional
RF  - 105
EDAT- 2007/01/30 09:00
MHDA- 2007/03/21 09:00
CRDT- 2007/01/30 09:00
PHST- 2007/01/30 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2007/01/30 09:00 [entrez]
PST - ppublish
SO  - Cell Mol Immunol. 2006 Dec;3(6):401-10.