PMID- 1725809
OWN - NLM
STAT- MEDLINE
DCOM- 19920603
LR  - 20190516
IS  - 0470-8105 (Print)
IS  - 0470-8105 (Linking)
VI  - 31
IP  - 10
DP  - 1991 Oct
TI  - Expression of MHC class II antigens on human glioma cells modulated by 
      transfection with genes encoding these antigens.
PG  - 623-8
AB  - Four glioma cell lines not expressing human leukocyte antigen (HLA)-DR or DQ did 
      so after transfection with genes encoding HLA-DR and DQ. The glioma cells had 
      enhanced ability to stimulate allogeneic and autologous responding lymphocytes in 
      the mixed lymphocyte response (MLR). Glioma cells expressing only HLA-DR had 
      weaker MLR enhancement than those expressing both HLA-DR and DQ or only HLA-DQ. 
      Stimulation by transformed glioma cells increased the killing activity of 
      responding lymphocytes against autologous glioma cells 2.0 times. Both HLA-DR and 
      DQ are important in MLR, and the immunogenicity of glioma cells might be 
      increased by transfection with genes encoding these antigens.
FAU - Yoshida, S
AU  - Yoshida S
AD  - Department of Neurosurgery, School of Medicine, Niigata University.
FAU - Takahashi, H
AU  - Takahashi H
FAU - Tanaka, R
AU  - Tanaka R
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Neurol Med Chir (Tokyo)
JT  - Neurologia medico-chirurgica
JID - 0400775
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Antigens, Neoplasm/*biosynthesis
MH  - Brain Neoplasms/immunology/*pathology
MH  - Cytotoxicity Tests, Immunologic
MH  - *Gene Expression Regulation, Neoplastic
MH  - Glioma/immunology/*pathology
MH  - HLA-DQ Antigens/*biosynthesis/genetics
MH  - HLA-DR Antigens/*biosynthesis/genetics
MH  - Humans
MH  - Lymphocytes/immunology
MH  - Recombinant Proteins/biosynthesis
MH  - Transfection
MH  - Tumor Cells, Cultured/immunology
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
AID - JST.Journalarchive/nmc1959/31.623 [pii]
AID - 10.2176/nmc.31.623 [doi]
PST - ppublish
SO  - Neurol Med Chir (Tokyo). 1991 Oct;31(10):623-8. doi: 10.2176/nmc.31.623.