PMID- 17259845
OWN - NLM
STAT- MEDLINE
DCOM- 20070319
LR  - 20091103
IS  - 0363-8715 (Print)
IS  - 0363-8715 (Linking)
VI  - 31
IP  - 1
DP  - 2007 Jan-Feb
TI  - Bronchiolitis obliterans organizing pneumonia after bone marrow transplantation: 
      association with human leukocyte antigens.
PG  - 132-7
AB  - This is the first study reporting the relationship between the development of 
      bronchiolitis obliterans organizing pneumonia (BOOP) and human leukocyte antigen 
      (HLA) in patients with bone marrow transplantation (BMT). The HLA B35 was 
      significantly higher in patients with BOOP than in patients without BOOP after 
      BMT (P = 0.0069). The HLA B35 is important as a host factor for the generation of 
      BOOP after BMT. OBJECTIVE: To assess the relationship between the development of 
      BOOP after BMT and HLA. METHODS: We retrospectively reviewed clinical features 
      and chest computed tomographic scans in 64 patients who underwent allogeneic BMT 
      between March 1990 and September 2004, and evaluated the relationship between HLA 
      and development of BOOP. RESULTS: Development of BOOP was between days 22 and 347 
      (mean, 114 days). The common computed tomographic findings consisted of patchy 
      consolidation in subpleural and/or peribronchovascular distributions. Frequency 
      of HLA B35 in patients with BOOP development after BMT was significantly higher 
      than in patients without BOOP after BMT (P = 0.0069). There were no significant 
      relationships between the others of this antigen and BOOP development. 
      CONCLUSIONS: Our results suggested that HLA B35 is an important host factor for 
      the generation of BOOP after BMT.
FAU - Yotsumoto, Sachie
AU  - Yotsumoto S
AD  - Department of Diagnostic and Interventional Radiology, Oita University Faculty of 
      Medicine, Oita, Japan.
FAU - Okada, Fumito
AU  - Okada F
FAU - Yotsumoto, Shinji
AU  - Yotsumoto S
FAU - Ando, Yumiko
AU  - Ando Y
FAU - Matsumoto, Shunro
AU  - Matsumoto S
FAU - Wakisaka, Masaki
AU  - Wakisaka M
FAU - Mori, Hiromu
AU  - Mori H
FAU - Ogata, Masao
AU  - Ogata M
FAU - Kikuchi, Hiroshi
AU  - Kikuchi H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Comput Assist Tomogr
JT  - Journal of computer assisted tomography
JID - 7703942
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Cryptogenic Organizing Pneumonia/*immunology
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2007/01/30 09:00
MHDA- 2007/03/21 09:00
CRDT- 2007/01/30 09:00
PHST- 2007/01/30 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2007/01/30 09:00 [entrez]
AID - 00004728-200701000-00021 [pii]
AID - 10.1097/01.rct.0000230010.39338.71 [doi]
PST - ppublish
SO  - J Comput Assist Tomogr. 2007 Jan-Feb;31(1):132-7. doi: 
      10.1097/01.rct.0000230010.39338.71.