PMID- 17261783
OWN - NLM
STAT- MEDLINE
DCOM- 20070313
LR  - 20070130
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1089
DP  - 2006 Nov
TI  - Clinical relevance of cytogenetics in myelodysplastic syndromes.
PG  - 395-410
AB  - Myelodysplastic syndromes (MDS) are a group of heterogeneous stem cell disorders 
      with different clinical behaviors and outcomes. Conventional cytogenetics (CC) 
      studies have demonstrated that the majority of MDS patients harbor clonal 
      chromosome defects. The probability of discovering a chromosomal abnormality has 
      been increased by fluorescence in situ hybridization (FISH), which has revealed 
      that about 15% of patients with a normal chromosome pattern on CC may instead 
      present cryptic defects. Cytogenetic abnormalities, except for the interstitial 
      long-arm deletion of chromosome 5 (5q-), are not specific for any 
      French-American-British (FAB)/World Health Organization (WHO) MDS subtypes, 
      demonstrate the clonality of the disease, and identify peculiar morphological 
      entities, thus confirming clinical diagnosis. In addition, chromosome 
      abnormalities are independent prognostic factors predicting overall survival and 
      the likelihood of progression in acute myeloid leukemia.
FAU - Bernasconi, Paolo
AU  - Bernasconi P
AD  - Department of Blood, Heart and Lung Medical Sciences of the University of Pavia 
      and Division of Hematology, Fondazione Policlinico San Matteo IRCCS, Pavia, 
      Italy. p.bernasconi@smatteo.pv.it
FAU - Boni, Marina
AU  - Boni M
FAU - Cavigliano, Paola Maria
AU  - Cavigliano PM
FAU - Calatroni, Silvia
AU  - Calatroni S
FAU - Giardini, Ilaria
AU  - Giardini I
FAU - Rocca, Barbara
AU  - Rocca B
FAU - Zappatore, Rita
AU  - Zappatore R
FAU - Dambruoso, Irene
AU  - Dambruoso I
FAU - Caresana, Marilena
AU  - Caresana M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 5/*genetics/ultrastructure
MH  - Chromosomes, Human, Pair 7/*genetics/ultrastructure
MH  - Cytogenetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Myelodysplastic Syndromes/*diagnosis/*mortality/pathology
MH  - Prognosis
RF  - 18
EDAT- 2007/01/31 09:00
MHDA- 2007/03/14 09:00
CRDT- 2007/01/31 09:00
PHST- 2007/01/31 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2007/01/31 09:00 [entrez]
AID - 1089/1/395 [pii]
AID - 10.1196/annals.1386.034 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2006 Nov;1089:395-410. doi: 10.1196/annals.1386.034.