PMID- 17263761
OWN - NLM
STAT- MEDLINE
DCOM- 20070813
LR  - 20171116
IS  - 0742-3071 (Print)
IS  - 0742-3071 (Linking)
VI  - 24
IP  - 3
DP  - 2007 Mar
TI  - Metformin improves skin capillary reactivity in normoglycaemic subjects with the 
      metabolic syndrome.
PG  - 272-9
AB  - AIMS: Insulin resistance and a parental history of diabetes mellitus are 
      independently associated with endothelial dysfunction. Oxidative stress has a 
      pivotal role in the pathophysiology of vascular injury. Metformin, in addition to 
      its glucose-lowering properties, has vasculoprotective effects. We investigated 
      whether metformin has beneficial effects on the nutritive skin capillary 
      circulation and deceases oxidative stress in a group at high risk for Type 2 
      diabetes mellitus (T2DM) and cardiovascular disease. METHODS: Thirty 
      normoglycaemic subjects with the metabolic syndrome (MS),who had first-degree 
      relatives with T2DM, participated. The mean age was 39.1 +/- 8.4 years and body 
      mass index (BMI) 35.7 +/- 4.8 kg/m2 (mean +/- SD). SUBJECTS: were randomized 1 : 
      1 to receive placebo (n=14) or metformin (n=16; 1700 mg/day) in a double-blind 
      study. At baseline and post treatment, blood and urine samples were collected for 
      biochemical and 8-epi-prostaglandin F2alpha (8-epi-PGF2alpha) analysis, 
      respectively. Microcirculation was assessed by nailfold videocapillaroscopy, 
      analysing afferent (AF), efferent (EF) and apical (AP) diameters of capillary 
      loops, functional capillary density (FCD), red blood cell velocity at rest 
      (RBCV), after 1 min arterial occlusion (RBCVmax) and time (TRBCVmax)taken to 
      reach it. RESULTS: Groups did not differ significantly in anthropometric, 
      clinical, laboratory or microvascular measurements at baseline. In the metformin 
      group, weight,BMI, systolic blood pressure and fasting plasma glucose fell, and 
      lipid profile and microcirculatory parameters FCD, AF, EF, AP, RBCVmaxand 
      TRBCVmax improved (all P<0.01). No relationship between clinico-laboratory 
      parameters and microvascular reactivity was observed, except for changes in total 
      and low density lipoprotein-cholesterol and RBCVmax* 8-epi-PGF2alpha did not 
      change significantly in either group. CONCLUSIONS: Metformin improved skin 
      capillary reactivity in normoglycaemic MS subjects independently of significant 
      changes in 8-epi-PGF2alpha levels.
FAU - Kraemer de Aguiar, L G
AU  - Kraemer de Aguiar LG
AD  - Department of Physiological Sciences, Laboratoriode Pesquisas em Microcirculacao, 
      State University of Rio de Janeiro, Rio de Janeiro, Brazil. gkraemer@ig.com.br
FAU - Laflor, C M
AU  - Laflor CM
FAU - Bahia, L
AU  - Bahia L
FAU - Villela, N R
AU  - Villela NR
FAU - Wiernsperger, N
AU  - Wiernsperger N
FAU - Bottino, D A
AU  - Bottino DA
FAU - Bouskela, E
AU  - Bouskela E
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
RN  - 0 (Hypoglycemic Agents)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Adult
MH  - Capillaries
MH  - Coronary Disease/*drug therapy
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Diabetic Angiopathies/*drug therapy
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Male
MH  - Metabolic Syndrome/*complications
MH  - Metformin/*therapeutic use
MH  - Microcirculation/physiology
MH  - Middle Aged
MH  - Oxidative Stress/physiology
MH  - Risk Factors
MH  - Skin/blood supply
EDAT- 2007/02/01 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/02/01 09:00
PHST- 2007/02/01 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/02/01 09:00 [entrez]
AID - DME2082 [pii]
AID - 10.1111/j.1464-5491.2007.02082.x [doi]
PST - ppublish
SO  - Diabet Med. 2007 Mar;24(3):272-9. doi: 10.1111/j.1464-5491.2007.02082.x.