PMID- 17267117
OWN - NLM
STAT- MEDLINE
DCOM- 20070522
LR  - 20221207
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 415
IP  - 2
DP  - 2007 Mar 26
TI  - No association between the brain-derived neurotrophic factor (BDNF) Val66Met 
      polymorphism and schizophrenia in Asian populations: Evidence from a case-control 
      study and meta-analysis.
PG  - 108-12
AB  - Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that plays an 
      important role in the development and maintenance of adult neurons and is 
      important regulator of synaptic plasticity in human brain. It has been reported 
      that there are alterations in BDNF levels in the brains of patients with 
      schizophrenia. It has also been reported that transneuronal transfer of BDNF is 
      dependent on neuronal activity, suggesting that BDNF plays an important role in 
      neurotransmission. A single nucleotide polymorphism (SNP) in the BDNF gene that 
      causes a valine to methionine substitution at codon 66 (Val66Met) has been 
      demonstrated to affect human memory and hippocampal function. A possible positive 
      association between the BDNF Val66Met polymorphism and schizophrenia has also 
      been shown in Scottish and Spanish populations. Furthermore, the BDNF Val66Met 
      polymorphism has been implicated in the age of onset of schizophrenia. In the 
      present study, we attempted to replicate these findings in a Japanese 
      case-control sample (211 patients with schizophrenia and 205 controls). We did 
      not find an association between the BDNF Val66Met polymorphism and schizophrenia. 
      An association between the Val66Met polymorphism and age of onset was not 
      observed either. Furthermore, a meta-analysis including the present and previous 
      Asian studies comparing 2059 patients with schizophrenia and 2765 controls also 
      revealed no significant association between the BDNF Val66Met polymorphism and 
      schizophrenia. Our results do not support a significant role for the BDNF 
      Val66Met polymorphism in the development of schizophrenia in Asian populations.
FAU - Naoe, Yui
AU  - Naoe Y
AD  - Department of Psychiatry, School of Medicine, University of Occupational and 
      Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan. 
      naoe_yui@yahoo.co.jp
FAU - Shinkai, Takahiro
AU  - Shinkai T
FAU - Hori, Hiroko
AU  - Hori H
FAU - Fukunaka, Yuko
AU  - Fukunaka Y
FAU - Utsunomiya, Kensuke
AU  - Utsunomiya K
FAU - Sakata, Shinichi
AU  - Sakata S
FAU - Matsumoto, Chima
AU  - Matsumoto C
FAU - Shimizu, Kazuko
AU  - Shimizu K
FAU - Hwang, Rudi
AU  - Hwang R
FAU - Ohmori, Osamu
AU  - Ohmori O
FAU - Nakamura, Jun
AU  - Nakamura J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070105
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Asian People/statistics & numerical data
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - DNA Mutational Analysis/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Meta-Analysis as Topic
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Schizophrenia/*genetics
MH  - Valine/*genetics
EDAT- 2007/02/03 09:00
MHDA- 2007/05/23 09:00
CRDT- 2007/02/03 09:00
PHST- 2006/08/31 00:00 [received]
PHST- 2006/12/29 00:00 [revised]
PHST- 2007/01/03 00:00 [accepted]
PHST- 2007/02/03 09:00 [pubmed]
PHST- 2007/05/23 09:00 [medline]
PHST- 2007/02/03 09:00 [entrez]
AID - S0304-3940(07)00019-5 [pii]
AID - 10.1016/j.neulet.2007.01.006 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Mar 26;415(2):108-12. doi: 10.1016/j.neulet.2007.01.006. Epub 
      2007 Jan 5.