PMID- 17267174
OWN - NLM
STAT- MEDLINE
DCOM- 20070920
LR  - 20131121
IS  - 0890-6238 (Print)
IS  - 0890-6238 (Linking)
VI  - 23
IP  - 3
DP  - 2007 Apr-May
TI  - Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic 
      hyperactivity at adolescence: critical periods for regional and sex-selective 
      effects.
PG  - 421-7
AB  - Fetal or neonatal chlorpyrifos (CPF) exposure affects serotonin (5HT) synaptic 
      function and related behaviors in adulthood. We examined the critical period and 
      dose threshold for effects on 5HT and assessed their emergence in adolescence. 
      Pregnant rats were given CPF (1 or 5mg/kg/day) from gestational days (GD)17-20 or 
      GD9-12 and 5HT levels and turnover were evaluated on postnatal day 30; the lower 
      dose lies below the threshold for inhibition of fetal brain cholinesterase. 
      GD17-20 exposure increased 5HT turnover in brain regions containing either 5HT 
      projections or cell bodies, with a preferential effect in males. Shifting the 
      exposure to GD9-12 also augmented 5HT activity but only in the cerebral cortex 
      and without sex preference. Similar, but lesser effects were seen for dopamine 
      turnover in the same regions. These results indicate that, in a critical 
      developmental period, apparently subtoxic exposures to CPF produce long-term 
      activation of 5HT systems.
FAU - Slotkin, Theodore A
AU  - Slotkin TA
AD  - Department of Pharmacology & Cancer Biology, Duke University Medical Center, Box 
      3813 DUMC, Durham, NC 27710, USA. t.slotkin@duke.edu
FAU - Seidler, Frederic J
AU  - Seidler FJ
LA  - eng
GR  - ES10356/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060801
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Insecticides)
RN  - 333DO1RDJY (Serotonin)
RN  - JCS58I644W (Chlorpyrifos)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/anatomy & histology/drug effects/metabolism/pathology
MH  - Chlorpyrifos/*toxicity
MH  - Dopamine/*metabolism
MH  - Female
MH  - Gestational Age
MH  - Hyperkinesis/chemically induced/metabolism/physiopathology
MH  - Insecticides/toxicity
MH  - Male
MH  - Neurons/drug effects/metabolism/pathology
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Presynaptic Terminals/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Sex Factors
EDAT- 2007/02/03 09:00
MHDA- 2007/09/21 09:00
CRDT- 2007/02/03 09:00
PHST- 2006/05/09 00:00 [received]
PHST- 2006/07/07 00:00 [revised]
PHST- 2006/07/25 00:00 [accepted]
PHST- 2007/02/03 09:00 [pubmed]
PHST- 2007/09/21 09:00 [medline]
PHST- 2007/02/03 09:00 [entrez]
AID - S0890-6238(06)00193-6 [pii]
AID - 10.1016/j.reprotox.2006.07.010 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2007 Apr-May;23(3):421-7. doi: 10.1016/j.reprotox.2006.07.010. 
      Epub 2006 Aug 1.