PMID- 1726810
OWN - NLM
STAT- MEDLINE
DCOM- 19921208
LR  - 20131121
IS  - 0261-3166 (Print)
IS  - 0261-3166 (Linking)
IP  - 25
DP  - 1991
TI  - Inhibitory effect of N3-methyl derivative of 3'-azido-3'-deoxythymidine 
      5'-triphosphate on the activity of HIV-1 reverse transcriptase.
PG  - 27-8
AB  - N3-Methyl derivative of 3'-azido-3'-deoxythymidine 5'-triphosphate (Me-AZTTP) 
      showed a potent inhibitory effect on HIV-1 reverse transcriptase using MS2 phage 
      RNA as the template. The inhibition mechanism of MeAZTTP was noncompetitive with 
      respect to any of the template MS2 RNA, dATP and dCTP. On the other hand, MeAZTTP 
      showed a mixed-type inhibition with respect to dGTP and dTTP. These results 
      indicate that MeAZTTP competes not only with dTTP but also with dGTP.
FAU - Nakane, H
AU  - Nakane H
AD  - Laboratory of Viral Oncology, Aichi Cancer Center Research Institute, Nagoya, 
      Japan.
FAU - Suzuki, A
AU  - Suzuki A
FAU - Nakata, Y
AU  - Nakata Y
FAU - Kitade, Y
AU  - Kitade Y
FAU - Hirota, K
AU  - Hirota K
FAU - Maki, Y
AU  - Maki Y
FAU - Ono, K
AU  - Ono K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nucleic Acids Symp Ser
JT  - Nucleic acids symposium series
JID - 8007206
RN  - 0 (Antiviral Agents)
RN  - 0 (Dideoxynucleotides)
RN  - 0 (RNA, Viral)
RN  - 0 (Reverse Transcriptase Inhibitors)
RN  - 0 (Thymine Nucleotides)
RN  - 142644-39-1 (N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate)
RN  - 4B9XT59T7S (Zidovudine)
RN  - EC 2.7.7.49 (HIV Reverse Transcriptase)
RN  - EC 2.7.7.49 (RNA-Directed DNA Polymerase)
SB  - IM
MH  - Antiviral Agents/chemistry/*pharmacology
MH  - Bacteriophages/genetics
MH  - Dideoxynucleotides
MH  - HIV Reverse Transcriptase
MH  - HIV-1/*drug effects/enzymology
MH  - Methylation
MH  - RNA, Viral/genetics
MH  - RNA-Directed DNA Polymerase/drug effects
MH  - *Reverse Transcriptase Inhibitors
MH  - Templates, Genetic
MH  - Thymine Nucleotides/*pharmacology
MH  - Zidovudine/*analogs & derivatives/pharmacology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
PST - ppublish
SO  - Nucleic Acids Symp Ser. 1991;(25):27-8.