PMID- 17268340
OWN - NLM
STAT- MEDLINE
DCOM- 20070627
LR  - 20070201
IS  - 0761-8425 (Print)
IS  - 0761-8425 (Linking)
VI  - 23
IP  - 5 Pt 3
DP  - 2006 Nov
TI  - [Stage IV non-small cell lung cancer. Duration of chemotherapy for locally 
      advanced non small cell lung cancers].
PG  - 16S72-16S77
AB  - BACKGROUND: Optimal duration of first line chemotherapy for non surgical non 
      small cell lung cancer (NSCLC) is still debated. It concerns the length of 
      initial chemotherapy and the use of maintenance treatments. METHODS: Literature 
      review was performed on maintenance and duration of chemotherapy. RESULTS: The 
      use of maintenance chemotherapy showed no differences in terms of survival. One 
      study (with gemcitabine as maintenance treatment) found a difference in terms of 
      time to progression. Several randomized clinical trials were carried out on 
      duration of chemotherapy. There were no impact on survival time. CONCLUSION: No 
      positive results were found with an increase of chemotherapeutic cycles. 
      Maintenance therapy needs more additive studies. ASCO guidelines may be currently 
      used.
FAU - Vergnenegre, A
AU  - Vergnenegre A
AD  - Service de Pathologie Respiratoire, Hopital du Cluzeau, CHU Dupyutren, Limoges, 
      France. alain.vergnenegre@unilim.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - CBNPC stade IV. Duree optimale de la chimiotherapie initiale des cancers non a 
      petites cellules localement avances.
PL  - France
TA  - Rev Mal Respir
JT  - Revue des maladies respiratoires
JID - 8408032
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy/*pathology
MH  - Disease Progression
MH  - Humans
MH  - Lung Neoplasms/*drug therapy/*pathology
MH  - Neoplasm Staging
MH  - Time Factors
RF  - 23
EDAT- 2007/02/03 09:00
MHDA- 2007/06/28 09:00
CRDT- 2007/02/03 09:00
PHST- 2007/02/03 09:00 [pubmed]
PHST- 2007/06/28 09:00 [medline]
PHST- 2007/02/03 09:00 [entrez]
AID - MDOI-RMR-11-2006-23-5-C3-0761-8425-101019-20064133 [pii]
PST - ppublish
SO  - Rev Mal Respir. 2006 Nov;23(5 Pt 3):16S72-16S77.