PMID- 17270809
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20070605
LR  - 20200309
IS  - 1557-170X (Print)
IS  - 1557-170X (Linking)
VI  - 2004
DP  - 2004
TI  - Development of a MEMS microsystem to study the effect of mechanical tension on 
      cerebral cortex neurogenesis.
PG  - 2607-10
AB  - A clamp-and-ratchet microstructure based on poly crystalline silicon 
      (polysilicon) microelectromechanical systems (MEMS) technology has been designed 
      to exert mechanical tension along radial glial processes between groups of neural 
      stem cells to study the effect of tension on cerebral cortex neurogenesis. FEA 
      analysis shows that the design should not fail under expected loading conditions. 
      Preliminary studies show that embryonic brain tissue survives under tension for 
      at least six days. Neurospheres have been successfully cultured on 
      Poly(dimethylsiloxane) (PDMS) for eight days and exhibit radial extensions which 
      appear to support neuronal migration. Stretching the PDMS using the clamp and 
      ratchet will produce tension in these radial extensions which may modulate 
      neuronal migration, a key process in cerebral cortex development.
FAU - Lin, Gisela
AU  - Lin G
AD  - Dept. of Biomed. Eng., California Univ., Irvine, CA, USA.
FAU - Wu, Vincent I
AU  - Wu VI
FAU - Hainley, Ryan E
AU  - Hainley RE
FAU - Flanagan, Lisa A
AU  - Flanagan LA
FAU - Monuki, Edwin S
AU  - Monuki ES
FAU - Tang, William C
AU  - Tang WC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Conf Proc IEEE Eng Med Biol Soc
JT  - Conference proceedings : ... Annual International Conference of the IEEE 
      Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and 
      Biology Society. Annual Conference
JID - 101243413
EDAT- 2007/02/03 09:00
MHDA- 2007/02/03 09:01
CRDT- 2007/02/03 09:00
PHST- 2007/02/03 09:00 [pubmed]
PHST- 2007/02/03 09:01 [medline]
PHST- 2007/02/03 09:00 [entrez]
AID - 10.1109/IEMBS.2004.1403749 [doi]
PST - ppublish
SO  - Conf Proc IEEE Eng Med Biol Soc. 2004;2004:2607-10. doi: 
      10.1109/IEMBS.2004.1403749.