PMID- 17272089 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20070918 LR - 20200309 IS - 1557-170X (Print) IS - 1557-170X (Linking) VI - 2004 DP - 2004 TI - Evaluation of three different kinetic models for use with myocardial perfusion MRI data. PG - 1922-4 AB - Coronary artery disease (CAD), a leading cause of death in the US and worldwide, can be effectively diagnosed and assessed using non-invasive myocardial perfusion MRI. Tracer kinetic models play a crucial role in the analysis and quantification of perfusion. In this work, we evaluate the performance of 3 different kinetic models used to analyze perfusion: (a) a modified 2-compartment model (b) the Johnson-Wilson (JW) model and (c) a modified JW model. We hypothesized that three different models would give statistically different results and that the modified JW model would be better than the other two because it would most closely model the underlying physiological processes. Results indicate that the models are statistically different from each other but the 2-compartment model is more stable than both models (b) and (c) and that the modified JW model is the most sensitive to ischemia as compared to the others. FAU - Vijayakumar, Sathya AU - Vijayakumar S AD - UCAIR, University of Utah, Salt Lake City, UT, USA. FAU - R Dibella, Edward AU - R Dibella E LA - eng PT - Journal Article PL - United States TA - Conf Proc IEEE Eng Med Biol Soc JT - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference JID - 101243413 EDAT- 2007/02/03 09:00 MHDA- 2007/02/03 09:01 CRDT- 2007/02/03 09:00 PHST- 2007/02/03 09:00 [pubmed] PHST- 2007/02/03 09:01 [medline] PHST- 2007/02/03 09:00 [entrez] AID - 10.1109/IEMBS.2004.1403569 [doi] PST - ppublish SO - Conf Proc IEEE Eng Med Biol Soc. 2004;2004:1922-4. doi: 10.1109/IEMBS.2004.1403569.