PMID- 17273135
OWN - NLM
STAT- MEDLINE
DCOM- 20070418
LR  - 20201105
IS  - 0399-8320 (Print)
IS  - 0399-8320 (Linking)
VI  - 31
IP  - 1
DP  - 2007 Jan
TI  - Proton pump inhibitors in general medicine. Comparison of routine practices with 
      marketing authorization indications.
PG  - 78-83
AB  - OBJECTIVE: To determine whether inaugural prescriptions for proton pump 
      inhibitors (PPI) written by general practitioners in the Grenoble region are in 
      non-compliance with the indications of the French drug marketing authorization. 
      METHODS: The study was conducted on all inaugural PPI prescriptions written by 
      general practitioners in Grenoble region between March 1 and March 31, 2004. 
      Analyses were performed on a random sample of 600 representative prescriptions. A 
      questionnaire was sent to the general practitioners who had written these 
      prescriptions. There were 255 responses which could be analyzed. RESULT: Among 
      the 19,983 prescriptions for PPIs written in March 2004, 4, 442 (22.8%) were 
      first-time treatments. 85.9% of them were issued by general practitioners. The 
      main reasons for prescription identified in the study sample were the association 
      with other drugs [56.1%; 95%CI 50.0-62.2], gastroesophageal reflux disease 
      [29.4%; 95%CI 23.8-35.0] and dyspepsia [11.4%; 95%CI 7.5-15.3]. The rate of 
      non-compliance with the marketing authorization was 46.3% [95%CI 40.2-52.4], 
      including 20.4% [95%CI 15.5-25.3] for inappropriate medical indications. 
      CONCLUSION: General practitioners were the principal prescribers of inaugural PPI 
      treatments. Even after excluding prescriptions which were non-compliant because 
      of a regulatory problem, one out of five prescriptions were written for 
      inappropriate medical indications.
FAU - Levy-Neumand, Olivier
AU  - Levy-Neumand O
AD  - Service du Controle Medical de l'Assurance Maladie, Grenoble. 
      olivier.levy-neumand@elsm-grenoble.cnamts.fr
FAU - Carniaux, Francois
AU  - Carniaux F
FAU - Bonaz, Bruno
AU  - Bonaz B
FAU - Durand, Aurelie
AU  - Durand A
FAU - Roblin, Xavier
AU  - Roblin X
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - France
TA  - Gastroenterol Clin Biol
JT  - Gastroenterologie clinique et biologique
JID - 7704825
RN  - 0 (Gastrointestinal Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Algorithms
MH  - Cross-Sectional Studies
MH  - *Drug Industry
MH  - Drug Prescriptions/*statistics & numerical data
MH  - *Family Practice
MH  - Female
MH  - France
MH  - Gastroesophageal Reflux/drug therapy
MH  - Gastrointestinal Agents/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Practice Guidelines as Topic
MH  - *Practice Patterns, Physicians'
MH  - *Proton Pump Inhibitors
MH  - Surveys and Questionnaires
EDAT- 2007/02/03 09:00
MHDA- 2007/04/19 09:00
CRDT- 2007/02/03 09:00
PHST- 2007/02/03 09:00 [pubmed]
PHST- 2007/04/19 09:00 [medline]
PHST- 2007/02/03 09:00 [entrez]
AID - s0399-8320(07)89330-4 [pii]
AID - 10.1016/s0399-8320(07)89330-4 [doi]
PST - ppublish
SO  - Gastroenterol Clin Biol. 2007 Jan;31(1):78-83. doi: 
      10.1016/s0399-8320(07)89330-4.