PMID- 17273554
OWN - NLM
STAT- MEDLINE
DCOM- 20070404
LR  - 20211203
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 117
IP  - 2
DP  - 2007 Feb
TI  - A link between protein translation and body weight.
PG  - 310-3
AB  - Nutrient overload induces obesity, a primary risk factor for type 2 diabetes. 
      Ribosomal biogenesis and protein synthesis, which are controlled by the mammalian 
      target of rapamycin (mTOR), are primary energy-consuming processes in cells. mTOR 
      phosphorylates and inactivates members of the eukaryotic translation initiation 
      factor 4E-binding (eIF4E-binding) protein (4E-BP) family, which are translational 
      repressors of 5' cap-dependent protein synthesis. In this issue of the JCI, Le 
      Bacquer et al. report that simultaneous deletion of both 4E-BP1 and 4E-BP2 in 
      mice results in insulin resistance, decreased energy expenditure, and increased 
      adipogenesis (see the related article beginning on page 387). These findings link 
      protein synthesis, insulin sensitivity, and body weight.
FAU - Rui, Liangyou
AU  - Rui L
AD  - Department of Molecular and Integrative Physiology, University of Michigan 
      Medical School, Ann Arbor, Michigan 48109, USA. ruily@umich.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Carrier Proteins)
RN  - 0 (Eukaryotic Initiation Factor-4E)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
CON - J Clin Invest. 2007 Feb;117(2):387-96. PMID: 17273556
MH  - Animals
MH  - Body Weight/*physiology
MH  - Carrier Proteins/metabolism
MH  - Energy Metabolism
MH  - Eukaryotic Initiation Factor-4E/metabolism
MH  - Glucose/metabolism
MH  - Humans
MH  - Mice
MH  - Models, Biological
MH  - *Protein Biosynthesis
MH  - Protein Kinases/metabolism
MH  - Ribosomal Protein S6 Kinases/metabolism
MH  - TOR Serine-Threonine Kinases
PMC - PMC1783829
EDAT- 2007/02/03 09:00
MHDA- 2007/04/05 09:00
PMCR- 2007/02/01
CRDT- 2007/02/03 09:00
PHST- 2007/02/03 09:00 [pubmed]
PHST- 2007/04/05 09:00 [medline]
PHST- 2007/02/03 09:00 [entrez]
PHST- 2007/02/01 00:00 [pmc-release]
AID - 31289 [pii]
AID - 10.1172/JCI31289 [doi]
PST - ppublish
SO  - J Clin Invest. 2007 Feb;117(2):310-3. doi: 10.1172/JCI31289.