PMID- 17273962
OWN - NLM
STAT- MEDLINE
DCOM- 20070405
LR  - 20221207
IS  - 0002-9297 (Print)
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Linking)
VI  - 80
IP  - 3
DP  - 2007 Mar
TI  - Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in 
      Asians.
PG  - 407-15
AB  - Because mitochondria play pivotal roles in both insulin secretion from the 
      pancreatic beta cells and insulin resistance of skeletal muscles, we performed a 
      large-scale association study to identify mitochondrial haplogroups that may 
      confer resistance against or susceptibility to type 2 diabetes mellitus (T2DM). 
      The study population comprised 2,906 unrelated Japanese individuals, including 
      1,289 patients with T2DM and 1,617 controls, and 1,365 unrelated Korean 
      individuals, including 732 patients with T2DM and 633 controls. The genotypes for 
      25 polymorphisms in the coding region of the mitochondrial genome were 
      determined, and the haplotypes were classified into 10 major haplogroups (i.e., 
      F, B, A, N9a, M7a, M7b, G, D4a, D4b, and D5). Multivariate logistic-regression 
      analysis with adjustment for age and sex revealed that the mitochondrial 
      haplogroup N9a was significantly associated with resistance against T2DM 
      (P=.0002) with an odds ratio of 0.55 (95% confidence interval 0.40-0.75). Even in 
      the modern environment, which is often characterized by satiety and physical 
      inactivity, this haplogroup might confer resistance against T2DM.
FAU - Fuku, Noriyuki
AU  - Fuku N
AD  - Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of 
      Gerontology, Tokyo, Japan.
FAU - Park, Kyong Soo
AU  - Park KS
FAU - Yamada, Yoshiji
AU  - Yamada Y
FAU - Nishigaki, Yutaka
AU  - Nishigaki Y
FAU - Cho, Young Min
AU  - Cho YM
FAU - Matsuo, Hitoshi
AU  - Matsuo H
FAU - Segawa, Tomonori
AU  - Segawa T
FAU - Watanabe, Sachiro
AU  - Watanabe S
FAU - Kato, Kimihiko
AU  - Kato K
FAU - Yokoi, Kiyoshi
AU  - Yokoi K
FAU - Nozawa, Yoshinori
AU  - Nozawa Y
FAU - Lee, Hong Kyu
AU  - Lee HK
FAU - Tanaka, Masashi
AU  - Tanaka M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070122
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (Blood Glucose)
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/*genetics
MH  - Blood Glucose
MH  - Case-Control Studies
MH  - DNA, Mitochondrial/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics/metabolism
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Insulin/metabolism
MH  - Insulin Resistance/*genetics
MH  - Insulin Secretion
MH  - Male
MH  - Middle Aged
MH  - Mitochondria/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Quantitative Trait Loci/genetics
PMC - PMC1821119
EDAT- 2007/02/03 09:00
MHDA- 2007/04/06 09:00
PMCR- 2007/09/01
CRDT- 2007/02/03 09:00
PHST- 2006/10/18 00:00 [received]
PHST- 2006/12/16 00:00 [accepted]
PHST- 2007/02/03 09:00 [pubmed]
PHST- 2007/04/06 09:00 [medline]
PHST- 2007/02/03 09:00 [entrez]
PHST- 2007/09/01 00:00 [pmc-release]
AID - S0002-9297(07)60090-1 [pii]
AID - 44287 [pii]
AID - 10.1086/512202 [doi]
PST - ppublish
SO  - Am J Hum Genet. 2007 Mar;80(3):407-15. doi: 10.1086/512202. Epub 2007 Jan 22.