PMID- 17275221
OWN - NLM
STAT- MEDLINE
DCOM- 20070503
LR  - 20070226
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 169
IP  - 2
DP  - 2007 Mar 8
TI  - Decreases in urinary pheromonal activities in male mice after exposure to 
      3-methylchoranthrene.
PG  - 137-44
AB  - Many classes of environmental pollutants, which are found at significant levels 
      in the environment, affect the reproductive functions. The gonadal functions of 
      various animals are regulated by pheromones excreted from mating partners. 
      Pheromones in male urine play essential roles in the sexual maturation of female 
      mice. Pheromones are received by sensory neurons in the vomeronasal organ, which 
      innervate to the accessory olfactory bulb (AOB). The effects of a typical 
      aromatic environmental pollutant (3-methylchoranthrene) on excretion of 
      pheromones from male mice were explored based on neuronal Fos responses of the 
      AOB of female mice. On days 1 and 3 after intraperitoneal administration of 
      3-methylchoranthrene (3-MC), the density of Fos-immunoreactive (Fos-ir) cells in 
      the AOB of female mice after exposure to urine excreted from the administered 
      males was lower than that after exposure to urine from non-administered males. 
      These results suggest that 3-MC blocks chemical communication from male to female 
      mice by reducing pheromonal activities.
FAU - Shiraiwa, Takeshi
AU  - Shiraiwa T
AD  - Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 
      060-0812, Japan.
FAU - Kamiyama, Naoya
AU  - Kamiyama N
FAU - Kashiwayanagi, Makoto
AU  - Kashiwayanagi M
LA  - eng
PT  - Journal Article
DEP - 20070108
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Air Pollutants)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Sex Attractants)
RN  - 0 (major urinary proteins)
RN  - 56-49-5 (Methylcholanthrene)
SB  - IM
MH  - Air Pollutants/*toxicity
MH  - Animals
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Methylcholanthrene/*toxicity
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Olfactory Bulb/metabolism
MH  - Proteins/metabolism
MH  - Proto-Oncogene Proteins c-fos/biosynthesis
MH  - Sex Attractants/*urine
MH  - Vomeronasal Organ/drug effects/metabolism
EDAT- 2007/02/06 09:00
MHDA- 2007/05/04 09:00
CRDT- 2007/02/06 09:00
PHST- 2006/08/25 00:00 [received]
PHST- 2006/12/24 00:00 [revised]
PHST- 2006/12/24 00:00 [accepted]
PHST- 2007/02/06 09:00 [pubmed]
PHST- 2007/05/04 09:00 [medline]
PHST- 2007/02/06 09:00 [entrez]
AID - S0378-4274(07)00002-1 [pii]
AID - 10.1016/j.toxlet.2006.12.010 [doi]
PST - ppublish
SO  - Toxicol Lett. 2007 Mar 8;169(2):137-44. doi: 10.1016/j.toxlet.2006.12.010. Epub 
      2007 Jan 8.