PMID- 17275731
OWN - NLM
STAT- MEDLINE
DCOM- 20070327
LR  - 20211203
IS  - 1359-6446 (Print)
IS  - 1359-6446 (Linking)
VI  - 12
IP  - 3-4
DP  - 2007 Feb
TI  - Targeting mammalian target of rapamycin (mTOR) for health and diseases.
PG  - 112-24
AB  - The macrolide rapamycin is used clinically to treat graft rejection and 
      restenosis. Mammalian target of rapamycin (mTOR) is a central controller of 
      cellular and organism growth that integrates nutrient and hormonal signals, and 
      regulates diverse cellular processes. New studies have linked mTOR to several 
      human diseases including cancer, diabetes, obesity, cardiovascular diseases and 
      neurological disorders. Recent data have also revealed that mTOR is involved in 
      the regulation of lifespan and in age-related diseases. These findings 
      demonstrate the importance of growth control in the pathology of major diseases 
      and overall human health, and underscore the therapeutic potential of the mTOR 
      pathway.
FAU - Tsang, Chi Kwan
AU  - Tsang CK
AD  - Department of Pharmacology and Cancer Institute of New Jersey (CINJ) Robert Wood 
      Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854 USA.
FAU - Qi, Haiyan
AU  - Qi H
FAU - Liu, Leroy F
AU  - Liu LF
FAU - Zheng, X F Steven
AU  - Zheng XF
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20061215
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
RN  - 0 (Immunosuppressive Agents)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
EIN - Drug Discov Today. 2008 Sep;13(17-18):824
MH  - Aging/drug effects
MH  - Animals
MH  - Chronic Disease/drug therapy
MH  - *Drug Delivery Systems
MH  - Drug Design
MH  - Humans
MH  - Immunosuppressive Agents/*pharmacology
MH  - Life Expectancy
MH  - Protein Kinases/drug effects/*physiology
MH  - Sirolimus/*agonists/*pharmacology
MH  - TOR Serine-Threonine Kinases
RF  - 103
EDAT- 2007/02/06 09:00
MHDA- 2007/03/28 09:00
CRDT- 2007/02/06 09:00
PHST- 2006/06/09 00:00 [received]
PHST- 2006/11/16 00:00 [revised]
PHST- 2006/12/07 00:00 [accepted]
PHST- 2007/02/06 09:00 [pubmed]
PHST- 2007/03/28 09:00 [medline]
PHST- 2007/02/06 09:00 [entrez]
AID - S1359-6446(06)00491-0 [pii]
AID - 10.1016/j.drudis.2006.12.008 [doi]
PST - ppublish
SO  - Drug Discov Today. 2007 Feb;12(3-4):112-24. doi: 10.1016/j.drudis.2006.12.008. 
      Epub 2006 Dec 15.