PMID- 1727669
OWN - NLM
STAT- MEDLINE
DCOM- 19920124
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 69
IP  - 1
DP  - 1992 Jan 1
TI  - Human T-cell leukemia virus type I associated lymphadenitis.
PG  - 239-48
AB  - Histopathologic changes in lymph nodes were examined from ten patients with mild 
      lymphadenopathy, a few atypical lymphocytes in their peripheral blood, skin 
      lesions, and proviral DNA of human T-cell leukemia virus type I (HTLV-I) in their 
      nodes. The proviral DNA of HTLV-I was detected by southern blot analysis, in situ 
      hybridization, and/or polymerase chain reaction techniques. The lymph nodes 
      showed preserved nodal architecture with diffuse infiltration of small to 
      intermediate-sized lymphocytes in association with scattered transformed 
      lymphocytes and a few immunoblast-like cells in the enlarged paracortex. The 
      infiltrating lymphocytes were positive for CD4, but neither rearrangement nor 
      deletion of T-cell receptors and immunoglobulin heavy chain genes was detected. 
      Eight of ten patients received no therapy, and all patients were alive and 
      healthy more than 5 months after the biopsies. The histologic findings resembled 
      those of a viral infection and could be distinguished from HTLV-I associated 
      lymphomas.
FAU - Ohshima, K
AU  - Ohshima K
AD  - Department of Pathology, School of Medicine, Fukuoka University, Japan.
FAU - Kikuchi, M
AU  - Kikuchi M
FAU - Masuda, Y
AU  - Masuda Y
FAU - Sumiyoshi, Y
AU  - Sumiyoshi Y
FAU - Eguchi, F
AU  - Eguchi F
FAU - Mohtai, H
AU  - Mohtai H
FAU - Takeshita, M
AU  - Takeshita M
FAU - Kimura, N
AU  - Kimura N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Antigens, CD)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, CD/analysis
MH  - Base Sequence
MH  - Blotting, Southern
MH  - Child, Preschool
MH  - Female
MH  - HTLV-I Infections/immunology/*pathology
MH  - Human T-lymphotropic virus 1/isolation & purification
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/pathology
MH  - Lymphadenitis/immunology/*microbiology/pathology
MH  - Male
MH  - Microscopy, Immunoelectron
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Nucleic Acid Hybridization
MH  - Polymerase Chain Reaction
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1002/1097-0142(19920101)69:1<239::aid-cncr2820690139>3.0.co;2-# [doi]
PST - ppublish
SO  - Cancer. 1992 Jan 1;69(1):239-48. doi: 
      10.1002/1097-0142(19920101)69:1<239::aid-cncr2820690139>3.0.co;2-#.