PMID- 17277352
OWN - NLM
STAT- MEDLINE
DCOM- 20071004
LR  - 20181113
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Print)
IS  - 1355-6037 (Linking)
VI  - 93
IP  - 9
DP  - 2007 Sep
TI  - Circulating endothelial progenitor cells and clinical outcome in patients with 
      congestive heart failure.
PG  - 1046-50
AB  - BACKGROUND: Circulating endothelial progenitor cells (EPCs) are increased in 
      conditions associated with ischaemia and can potentially support angiogenesis and 
      vasculogenesis. EPC levels were also shown to predict outcome in patients with 
      atherosclerotic vascular disease. We tested the hypothesis that circulating EPC 
      can predict outcome in patients with congestive heart failure (CHF). METHODS: 
      EPC-colony-forming units were measured in the peripheral blood of 107 consecutive 
      patients with CHF with New York Heart Association (NYHA) functional class II-IV. 
      Serum levels of vascular endothelial growth factor (VEGF), N-terminal pro-B-type 
      natriuretic peptide (NT-pro-BNP) and high-sensitivity C-reactive protein (hsCRP) 
      were also measured. End points were defined as CHF-related hospital admissions 
      and all-cause mortality. RESULTS: Age (p = 0.01), diabetes mellitus (p = 0.002) 
      and EPC levels (p = 0.02) were found to be independent predictors of all-cause 
      mortality. EPC levels did not predict CHF-related hospitalisations. EPC levels 
      correlated positively with NYHA (p = 0.05, r = 0.19), but did not correlate with 
      VEGF, NT-pro-BNP or hsCRP. EPC levels did not differ by the aetiology of CHF. 
      CONCLUSIONS: EPC levels are independent predictors of all-cause mortality among 
      patients with CHF.
FAU - Michowitz, Yoav
AU  - Michowitz Y
AD  - The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
FAU - Goldstein, Emil
AU  - Goldstein E
FAU - Wexler, Dov
AU  - Wexler D
FAU - Sheps, David
AU  - Sheps D
FAU - Keren, Gad
AU  - Keren G
FAU - George, Jacob
AU  - George J
LA  - eng
PT  - Journal Article
DEP - 20070203
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Colony-Forming Units Assay
MH  - Endothelial Cells/*physiology
MH  - Endothelium, Vascular/pathology
MH  - Female
MH  - Heart Failure/*blood/pathology
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Prognosis
MH  - Risk Factors
MH  - Stem Cells/*physiology
MH  - Survival Analysis
MH  - Vascular Endothelial Growth Factor A/blood
PMC - PMC1955007
COIS- Competing interests: None declared.
EDAT- 2007/02/06 09:00
MHDA- 2007/10/05 09:00
PMCR- 2010/09/01
CRDT- 2007/02/06 09:00
PHST- 2007/02/06 09:00 [pubmed]
PHST- 2007/10/05 09:00 [medline]
PHST- 2007/02/06 09:00 [entrez]
PHST- 2010/09/01 00:00 [pmc-release]
AID - hrt.2006.102657 [pii]
AID - ht102657 [pii]
AID - 10.1136/hrt.2006.102657 [doi]
PST - ppublish
SO  - Heart. 2007 Sep;93(9):1046-50. doi: 10.1136/hrt.2006.102657. Epub 2007 Feb 3.