PMID- 17277946
OWN - NLM
STAT- MEDLINE
DCOM- 20070815
LR  - 20181113
IS  - 0340-0131 (Print)
IS  - 0340-0131 (Linking)
VI  - 80
IP  - 5
DP  - 2007 Apr
TI  - Micronucleus frequency in peripheral blood lymphocytes and buccal mucosa cells of 
      copper smelter workers, with special regard to arsenic exposure.
PG  - 371-80
AB  - Occupational exposure in copper smelters may produce various adverse health 
      effects including cancer which, according to available epidemiologic data, is 
      associated mainly with exposure to arsenic. Despite a number of well-documented 
      studies reporting an increased risk of cancer among copper smelters workers, the 
      data on genotoxic effects in this industry are scarce. In view of the above, an 
      assessment of micronuclei (MN) frequency in peripheral blood lymphocytes and 
      buccal epithelial cells from copper smelter workers was undertaken. Additionally, 
      the clastogenic/aneugenic effect in lymphocytes was assessed with the 
      fluorescence in situ hybridization (FISH). The study was conducted in three 
      copper smelters in southwestern Poland. The subjects (n = 72) were enrolled among 
      male workers at departments where As concentration in the air was up to at 80 
      microg/m(3). Exposure was assessed by measurement of arsenic concentration in 
      urine and toenail samples. The control group (n = 83) was recruited from healthy 
      male individuals living in central Poland who did not report any exposure to 
      known genotoxins. The results of our study showed a significant increase in MN 
      frequency in peripheral blood lymphocytes and in buccal epithelial cells of 
      smelter workers, compared to the controls (7.96 +/- 4.28 vs. 3.47 +/- 1.70 and 
      0.98 +/- 0.76 vs. 0.50 +/- 0.52, respectively). The FISH technique revealed the 
      presence of clastogenic and aneugenic effects in peripheral blood lymphocytes in 
      both groups. The clastogenic effect was slightly more pronounced in the smelter 
      workers; however, the difference was not statistically significant. The mean 
      arsenic concentrations in urine (total arsenic species) and in toenail samples in 
      the exposed group were 54.04 +/- 42.26 microg/l and 7.63 +/- 7.24 microg/g, 
      respectively, being significantly different from control group 11.01 +/- 10.84 
      microg/l and 0.51 +/- 0.05 microg/g. No correlation between As content in urine 
      or toenail samples and the genotoxic effect was found under study.
FAU - Lewinska, D
AU  - Lewinska D
AD  - Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational 
      Medicine, 8 Teresy St., 90-950, Lodz, Poland. dobrysia@imp.lodz.pl
FAU - Palus, J
AU  - Palus J
FAU - Stepnik, M
AU  - Stepnik M
FAU - Dziubaltowska, E
AU  - Dziubaltowska E
FAU - Beck, J
AU  - Beck J
FAU - Rydzynski, K
AU  - Rydzynski K
FAU - Natarajan, A T
AU  - Natarajan AT
FAU - Nilsson, R
AU  - Nilsson R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070203
PL  - Germany
TA  - Int Arch Occup Environ Health
JT  - International archives of occupational and environmental health
JID - 7512134
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - Adult
MH  - Arsenic Poisoning/blood/*genetics/urine
MH  - *Copper
MH  - Humans
MH  - Industry
MH  - *Lymphocytes/blood
MH  - Male
MH  - Micronuclei, Chromosome-Defective/*chemically induced
MH  - Middle Aged
MH  - Mouth Mucosa/*physiopathology
MH  - *Occupational Exposure
MH  - Poland
EDAT- 2007/02/06 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/02/06 09:00
PHST- 2005/07/04 00:00 [received]
PHST- 2006/06/27 00:00 [accepted]
PHST- 2007/02/06 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/02/06 09:00 [entrez]
AID - 10.1007/s00420-006-0130-7 [doi]
PST - ppublish
SO  - Int Arch Occup Environ Health. 2007 Apr;80(5):371-80. doi: 
      10.1007/s00420-006-0130-7. Epub 2007 Feb 3.