PMID- 17278028
OWN - NLM
STAT- MEDLINE
DCOM- 20070427
LR  - 20161124
IS  - 1439-7595 (Print)
IS  - 1439-7595 (Linking)
VI  - 17
IP  - 1
DP  - 2007
TI  - CD8+ T lymphocytes infiltrate predominantly in the inflammatory foci of 
      MPO-ANCA-positive thoracic hypertrophic pachymeningitis in a patient with 
      HLA-A24.
PG  - 75-80
AB  - Hypertrophic pachymeningitis (HP) is extremely rare and an inflammatory process 
      that thickens the dura mater. A 59-year-old Japanese woman developed backache, 
      became paraplegic, and magnetic resonance imaging revealed diffuse thickening of 
      the thoracic dura mater encompassing the spinal cord. Although a test for 
      myeloperoxidase antineutrophil cytoplasmic autoantibody (MPO-ANCA) was shown to 
      be positive, vasculitis was not found and CD8(+) T lymphocytes that predominated 
      in the inflammatory foci. Both interleukin (IL)-2 and IL-6 were markedly elevated 
      in not only sera but also cerebrospinal fluids, very much higher in the latter. 
      Human leukocyte antigen (HLA) typing revealed A24 positivity, suggesting this 
      molecule was interacting with CD8(+) T lymphocytes. It was suggested that 
      immunological disharmony and autoimmunity would play a pivotal role in the 
      development of HP under genetic background of HLA-A24, and HP would be one 
      feature of multiple organ involvement in ANCA-associated diseases.
FAU - Nakamura, Tadashi
AU  - Nakamura T
AD  - Section of Internal Medicine and Rheumatology, Kumamoto Center for Arthritis and 
      Rheumatology, 1-15-7 Kuhonji, Kumamoto 862-0976, Japan. 
      naktrkme@koh.marutakai.or.jp
FAU - Hirakawa, Kei
AU  - Hirakawa K
FAU - Higashi, Syu-ichi
AU  - Higashi S
FAU - Tomoda, Kunihiko
AU  - Tomoda K
FAU - Tsukano, Michishi
AU  - Tsukano M
FAU - Iyama, Ken-ichi
AU  - Iyama K
FAU - Sakae, Terumi
AU  - Sakae T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20070220
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A24 Antigen)
RN  - 0 (Immunosuppressive Agents)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Aged
MH  - Antibodies, Antineutrophil Cytoplasmic/drug effects/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Dura Mater/diagnostic imaging/*pathology
MH  - Female
MH  - HLA-A Antigens
MH  - HLA-A24 Antigen
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Laminectomy
MH  - Male
MH  - Meningitis, Aseptic/drug therapy/*immunology
MH  - Middle Aged
MH  - Peroxidase/drug effects/*immunology
MH  - Radiography
MH  - Spinal Cord/diagnostic imaging/*pathology/surgery
RF  - 35
EDAT- 2007/02/06 09:00
MHDA- 2007/04/28 09:00
CRDT- 2007/02/06 09:00
PHST- 2006/06/29 00:00 [received]
PHST- 2006/10/25 00:00 [accepted]
PHST- 2007/02/06 09:00 [pubmed]
PHST- 2007/04/28 09:00 [medline]
PHST- 2007/02/06 09:00 [entrez]
AID - 10.1007/s10165-006-0537-8 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2007;17(1):75-80. doi: 10.1007/s10165-006-0537-8. Epub 2007 Feb 
      20.