PMID- 17278214
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20190430
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 13
IP  - 4
DP  - 2007 Jan 28
TI  - Chromosome 11 aneusomy in esophageal cancers and precancerous lesions--an early 
      event in neoplastic transformation: an interphase fluorescence in situ 
      hybridization study from south India.
PG  - 503-8
AB  - AIM: To detect aneusomic changes with respect to chromosome 11 copy number in 
      esophageal precancers and cancers wherein the generation of cancer-specific 
      phenotypes is believed to be associated with specific chromosomal aneuploidies. 
      METHODS: We performed fluorescence in situ hybridization (FISH) on esophageal 
      tissue paraffin sections to analyze changes in chromosome 11 copy number using 
      apotome-generated images by optical sectioning microscopy. Sections were prepared 
      from esophageal tumor tissue, tissues showing preneoplastic changes and 
      histologically normal tissues (control) obtained from patients referred to the 
      clinic for endoscopic evaluation. RESULTS: Our results demonstrated that aneusomy 
      was seen in all the cancers and preneoplastic tissues, while none of the controls 
      showed aneusomic cells. There was no increase in aneusomy from precancers to 
      cancers. CONCLUSION: Our results suggest that evaluation of chromosome 11 
      aneusomy in esophageal tissue using FISH with an appropriate signal 
      capture-analysis system, can be used as an ancillary molecular marker predictive 
      of early neoplastic changes. Future studies can be directed towards the genes on 
      chromosome 11, which may play a role in the neoplastic transformation of 
      esophageal precancerous lesions to cancers.
FAU - Mohan, Vasavi
AU  - Mohan V
AD  - Department of Genetics & Molecular Medicine, Kamineni Hospitals, LB Nagar, 
      Hyderabad 500068, Andhra Pradesh, India. greenpastures@gmail.com
FAU - Ponnala, Shivani
AU  - Ponnala S
FAU - Reddy, Hemakumar M
AU  - Reddy HM
FAU - Sistla, Radha
AU  - Sistla R
FAU - Jesudasan, Rachel A
AU  - Jesudasan RA
FAU - Ahuja, Yog Raj
AU  - Ahuja YR
FAU - Hasan, Qurratulain
AU  - Hasan Q
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
MH  - Aneuploidy
MH  - *Cell Transformation, Neoplastic
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 11
MH  - Esophageal Neoplasms/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Precancerous Conditions/*genetics
PMC - PMC4065970
EDAT- 2007/02/06 09:00
MHDA- 2007/03/21 09:00
PMCR- 2007/01/28
CRDT- 2007/02/06 09:00
PHST- 2007/02/06 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2007/02/06 09:00 [entrez]
PHST- 2007/01/28 00:00 [pmc-release]
AID - 10.3748/wjg.v13.i4.503 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2007 Jan 28;13(4):503-8. doi: 10.3748/wjg.v13.i4.503.