PMID- 17281587
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20080912
LR  - 20200309
IS  - 1557-170X (Print)
IS  - 1557-170X (Linking)
VI  - 2005
DP  - 2005
TI  - A simple model of dynamic interactions between respiratory centers.
PG  - 5840-2
AB  - There is a general consensus that neurons responsible for the generation of a 
      respiratory rhythm are located in the rostral ventrolateral medulla. However, 
      there is still controversy regarding the necessary components for respiratory 
      rhythm generation. Both inspiratory neurons in the preBotzinger Complex (preBOtC) 
      and pre-inspiratory neurons located more rostrally to this anatomical structure 
      referred to as the parafacial respiratory group (pFRG) have been proposed to be 
      essential for respiratory rhythmogenesis. To study the dynamical interactions 
      between preBOtC and pFRG neurons, we use a canonical model that describes each 
      neuron population as a phase oscillator. We assume that the oscillators are 
      weakly coupled with pFRG neurons providing stimulation to preBOtC neurons and 
      preBOtC neurons providing inhibitory drive to pFRG neurons. In our mathematical 
      study, we explore plausible mechanisms that may account for the complex 
      interactions between I and pre-I neuron. In particular, we show that reduced 
      excitability of inspiratory in preBOtC may lead to the phenomena known as 
      "quantal slowing".
FAU - Joseph, I M P
AU  - Joseph IM
AD  - Laboratory for Neuroengineering, Georgia Institute of Technology, Atlanta, GA.
FAU - Butera, R J
AU  - Butera RJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Conf Proc IEEE Eng Med Biol Soc
JT  - Conference proceedings : ... Annual International Conference of the IEEE 
      Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and 
      Biology Society. Annual Conference
JID - 101243413
EDAT- 2007/02/07 09:00
MHDA- 2007/02/07 09:01
CRDT- 2007/02/07 09:00
PHST- 2007/02/07 09:00 [pubmed]
PHST- 2007/02/07 09:01 [medline]
PHST- 2007/02/07 09:00 [entrez]
AID - 10.1109/IEMBS.2005.1615817 [doi]
PST - ppublish
SO  - Conf Proc IEEE Eng Med Biol Soc. 2005;2005:5840-2. doi: 
      10.1109/IEMBS.2005.1615817.