PMID- 17283579
OWN - NLM
STAT- MEDLINE
DCOM- 20070314
LR  - 20231213
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 16
IP  - 1
DP  - 2007
TI  - Fine specificity of the Ro/SSA autoantibody response in relation to serological 
      and clinical findings in 96 patients with self-reported cutaneous symptoms 
      induced by the sun.
PG  - 10-7
AB  - Anti-Ro/SSA assays assist the clinician in distinguishing autoimmune diseases 
      such as Sjogrens syndrome (SS), systemic lupus erythematosus (SLE) and subacute 
      cutaneous lupus erythematosus (SCLE). The objective of the study was to 
      investigate the fine specificity of the autoantibodies in relation to clinical 
      presentation as well as environmental and endogenous factors such as 
      photosensitivity, smoking and immunoglobulin (Ig) levels in patients with Ro/SSA 
      autoantibodies. Serum samples from 96 anti-Ro/SSA positive photosensitive 
      patients were tested for autoantibody levels by enzyme-linked immunosorbent assay 
      (ELISA) using purified recombinant Ro52 kd, Ro60 kd and La proteins as antigens. 
      The highest levels of anti-Ro52 and anti-La were observed in patients with 
      primary SS, and the lowest levels of anti-Ro52 in chronic cutaneous lupus 
      erythematosus (CCLE). SCLE patients with systemic disease (SLE and/or SS) showed 
      higher levels of anti-Ro52 than SCLE limited to the skin. A correlation between 
      high serum levels of IgG and anti-Ro52 (P < 0.01) and between IgA and anti-Ro52 
      (P < 0.05) and anti-Ro60 (P < 0.05) was found. Polymorphic light eruption (PLE) 
      was common in all diagnostic groups but did not correlate with autoantibody 
      levels. Smoking was more common in lupus patients than in SS patients. Our 
      findings thus propose different mechanisms for different clinical presentations 
      of Ro/SSA positive patients. The testing of anti-Ro52 antibodies might serve as a 
      prognostic tool in photosensitive cutaneous diseases.
FAU - Popovic, K
AU  - Popovic K
AD  - Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, 
      Department of Dermatology, Stockholm, Sweden. karin.popovic@ki.se
FAU - Brauner, S
AU  - Brauner S
FAU - Ek, M
AU  - Ek M
FAU - Wahren-Herlenius, M
AU  - Wahren-Herlenius M
FAU - Nyberg, F
AU  - Nyberg F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantigens)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (SS-A antibodies)
RN  - 0 (SS-A antigen)
RN  - 0 (SS-B antibodies)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Antinuclear/*blood/immunology
MH  - Antibody Specificity
MH  - Antibody-Producing Cells/immunology
MH  - Arthritis, Rheumatoid/diagnosis/epidemiology/immunology
MH  - Autoantigens/immunology
MH  - Biopsy
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Lupus Erythematosus, Cutaneous/diagnosis/*epidemiology/etiology/pathology
MH  - Lupus Erythematosus, Systemic/diagnosis/epidemiology/immunology
MH  - Male
MH  - Middle Aged
MH  - Photosensitivity Disorders/blood/etiology/*immunology
MH  - Prevalence
MH  - Ribonucleoproteins/*immunology
MH  - Sjogren's Syndrome/diagnosis/epidemiology/immunology
MH  - Skin/pathology
MH  - Smoking/epidemiology
MH  - Sunlight/*adverse effects
MH  - Sweden/epidemiology
MH  - SS-B Antigen
EDAT- 2007/02/08 09:00
MHDA- 2007/03/16 09:00
CRDT- 2007/02/08 09:00
PHST- 2007/02/08 09:00 [pubmed]
PHST- 2007/03/16 09:00 [medline]
PHST- 2007/02/08 09:00 [entrez]
AID - 10.1177/0961203306073135 [doi]
PST - ppublish
SO  - Lupus. 2007;16(1):10-7. doi: 10.1177/0961203306073135.