PMID- 17284093
OWN - NLM
STAT- MEDLINE
DCOM- 20070405
LR  - 20181113
IS  - 1172-7047 (Print)
IS  - 1172-7047 (Linking)
VI  - 21
IP  - 2
DP  - 2007
TI  - Pharmacological treatment of the psychosis of Alzheimer's disease: what is the 
      best approach?
PG  - 101-15
AB  - Psychosis of Alzheimer's disease (PAD) forms part of the behavioural and 
      psychological symptoms of dementia (BPSD). PAD includes symptoms of psychosis 
      such as hallucinations or delusions, and may be associated with agitation, 
      negative symptoms or depression. Even though the US FDA has not approved any 
      medication for the treatment of PAD, atypical antipsychotics have been widely 
      used and favoured by geriatric experts in the management of the condition in view 
      of their modest efficacy and relative safety. However, the recent FDA warnings 
      regarding the cardiac, metabolic, cerebrovascular and mortality risks associated 
      with the use of these drugs in elderly patients with dementia have caused serious 
      concerns regarding their use. Nevertheless, until an effective and safe 
      medication is approved by the regulatory agencies for PAD, clinicians do not have 
      a better choice than atypical antipsychotics for the management of the serious 
      symptoms of this condition.
FAU - Madhusoodanan, Subramoniam
AU  - Madhusoodanan S
AD  - St John's Episcopal Hospital, 327 Beach 19th Street, Far Rockaway, New York 
      11691, USA. sdanan@ehs.org
FAU - Shah, Payal
AU  - Shah P
FAU - Brenner, Ronald
AU  - Brenner R
FAU - Gupta, Sanjay
AU  - Gupta S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - New Zealand
TA  - CNS Drugs
JT  - CNS drugs
JID - 9431220
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Alzheimer Disease/*complications
MH  - Antipsychotic Agents/classification/*therapeutic use
MH  - Disease Progression
MH  - Humans
MH  - Mental Disorders/*drug therapy/*etiology
RF  - 87
EDAT- 2007/02/08 09:00
MHDA- 2007/04/06 09:00
CRDT- 2007/02/08 09:00
PHST- 2007/02/08 09:00 [pubmed]
PHST- 2007/04/06 09:00 [medline]
PHST- 2007/02/08 09:00 [entrez]
AID - 2122 [pii]
AID - 10.2165/00023210-200721020-00002 [doi]
PST - ppublish
SO  - CNS Drugs. 2007;21(2):101-15. doi: 10.2165/00023210-200721020-00002.