PMID- 17284171
OWN - NLM
STAT- MEDLINE
DCOM- 20070710
LR  - 20200418
IS  - 1462-5814 (Print)
IS  - 1462-5822 (Electronic)
IS  - 1462-5814 (Linking)
VI  - 9
IP  - 2
DP  - 2007 Feb
TI  - Viruses and dendritic cells: enemy mine.
PG  - 279-89
AB  - Dendritic cells (DCs) act not only as sentinels for detection of, but also as 
      target cells for viruses, and this can be important for viral transport and 
      spread. All subsets of DCs are equipped with a battery of receptors recognizing 
      virus-associated molecular signatures, and recognition of those launches a 
      maturation programme that results in substantial alterations of morphology, 
      motility and the DCs' interactive properties with the extracellular matrix and 
      scanning T cells. In addition to being sensed, viruses are internalized into DCs 
      and, for the major proportion, processed into peptides that are subsequently 
      presented by major histocompatibility complex (MHC) molecules. Transmission of 
      virus to T cells can occur after completion of their replication cycle if the 
      intracellular milieu of the DC permits that. Alternatively, viruses can remain 
      protected from degradation following entrapment by pattern recognition receptors 
      in intracellular compartments, also referred to as virosomes, which translocate 
      towards the DC/T cell interface. Most likely, transfer of virus to T cells occurs 
      in these junctions, referred to as infectious synapses. In addition to promoting 
      DC maturation, many viruses are able to downmodulate DC development and functions 
      in order to evade immune recognition or to induce a generalized 
      immunosuppression.
FAU - Pohl, Christine
AU  - Pohl C
AD  - University of Wuerzburg, Institute for Virology and Immunobiology, Versbacher 
      Str. 7, D-97078 Wuerzburg, Germany.
FAU - Shishkova, Joana
AU  - Shishkova J
FAU - Schneider-Schaulies, Sibylle
AU  - Schneider-Schaulies S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - India
TA  - Cell Microbiol
JT  - Cellular microbiology
JID - 100883691
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Dendritic Cells/immunology/*virology
MH  - Humans
MH  - T-Lymphocytes/immunology/*virology
MH  - Virus Physiological Phenomena
MH  - Viruses/pathogenicity
PMC - PMC7162204
EDAT- 2007/02/08 09:00
MHDA- 2007/07/11 09:00
PMCR- 2020/04/16
CRDT- 2007/02/08 09:00
PHST- 2007/02/08 09:00 [pubmed]
PHST- 2007/07/11 09:00 [medline]
PHST- 2007/02/08 09:00 [entrez]
PHST- 2020/04/16 00:00 [pmc-release]
AID - CMI863 [pii]
AID - 10.1111/j.1462-5822.2006.00863.x [doi]
PST - ppublish
SO  - Cell Microbiol. 2007 Feb;9(2):279-89. doi: 10.1111/j.1462-5822.2006.00863.x.