PMID- 17284422
OWN - NLM
STAT- MEDLINE
DCOM- 20090327
LR  - 20190922
IS  - 0253-9772 (Print)
IS  - 0253-9772 (Linking)
VI  - 29
IP  - 1
DP  - 2007 Jan
TI  - [An association study between GRIN1, BDNF genes and bipolar disorder].
PG  - 41-6
AB  - To evaluate the role of inherited gene variations in GRIN1 (glutamate receptor, 
      ionotropic NMDA1), BDNF (brain derived neurotrophic factor) genes in human 
      bipolar disorder, we selected 4 single nucleotide polymorphisms in GRIN1, BDNF (2 
      SNPs in each gene) and made SNPs analysis in 100 unrelated cases and 100 controls 
      by TaqMan. Then we compared genotypes differences between cases and controls. The 
      software SHEsis was also used to make haplotype analysis. The significant results 
      were obtained, showing that the SNPs in GRIN1 gene were related to the BP (P < 
      0.05). In addition, the combined haplotype T/G had a significant difference in 
      the two groups (P < 0.05). The SNPs in BDNF gene showed no statistical 
      significance. These results confirm that the GRIN1 gene confers susceptibility to 
      bipolar disorder.
FAU - Liu, Min
AU  - Liu M
AD  - Beijing Anding Hospital Affiliated to the Capital University of Medical Sciences, 
      Beijing, China. shuerya@163.com
FAU - Ling, Si-Hai
AU  - Ling SH
FAU - Li, Wen-Biao
AU  - Li WB
FAU - Wang, Chuan-Yue
AU  - Wang CY
FAU - Chen, Da-Fang
AU  - Chen DF
FAU - Wang, Gang
AU  - Wang G
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Yi Chuan
JT  - Yi chuan = Hereditas
JID - 9436478
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carrier Proteins)
RN  - 0 (GRIN1 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Carrier Proteins/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Tissue Proteins/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Receptors, N-Methyl-D-Aspartate/*genetics
MH  - Young Adult
EDAT- 2007/02/08 09:00
MHDA- 2009/03/28 09:00
CRDT- 2007/02/08 09:00
PHST- 2007/02/08 09:00 [pubmed]
PHST- 2009/03/28 09:00 [medline]
PHST- 2007/02/08 09:00 [entrez]
AID - 0253-9772(2007)01-41-06 [pii]
AID - 10.1360/yc-007-0041 [doi]
PST - ppublish
SO  - Yi Chuan. 2007 Jan;29(1):41-6. doi: 10.1360/yc-007-0041.