PMID- 17285974
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20140625
VI  - 20
IP  - 23
DP  - 2006 Dec
TI  - [Study on the expression of angiogenesis and spontaneous apoptosis and their 
      relevance in laryngeal squamous cell carcinoma].
PG  - 1082-4
AB  - OBJECTIVE: To investigate the relationship among angiogenesis, spontaneous 
      apoptosis and clinicopathological parameters in laryngeal squamous cell carcinoma 
      (LSCC). METHOD: The intratumor microvessel density (IMVD), apoptotic index (AI) 
      and vascular endothelial growth factor (VEGF) expression were detected by 
      immunohistochemistry SABC and terminal uridine deoxynucleotidyl transferase 
      mediated nick end labeling(TUNEL) methods in 34 LSCC patients. RESULT: The 
      average IMVD was (21.50 +/- 8.87), and median of AI was 1.15%. The average IMVD 
      in positive and negative cervical lymphatic metastasis was (26.33 +/- 9.70) and 
      (17.68 +/- 6.06) respectively, and the IMVD with positive lymphatic metastasis 
      tumors was statistical significantly higher than those with negative cervical 
      lymphatic metastasis tumors (P < 0.01). The average IMVD had statistical 
      difference in histological grading (P < 0.01), and analysis by one to one, the 
      average IMVD had statistical difference between high and median grading. 
      Expression of VEGF had a significantly positive correlation with IMVD (r = 0.51, 
      P < 0.01). Statistical analysis revealed a significantly inverse correlation 
      between AI and IMVD (r = -0.53, P < 0.01). We failed to find the statistical 
      difference between IMVD and tumor T-stage in LSCC. CONCLUSION: IMVD may be an 
      important indicator to predict cervical lymphatic metastasis in LSCC. VEGF might 
      be an important angiogenic factor, and could promote tumor angiogenesis in LSCC. 
      Tumor angiogenesis might contribute to tumor malignant progression by inhibiting 
      spontaneous apoptosis in LSCC.
FAU - Zheng, Haizhou
AU  - Zheng H
AD  - Department of Otolaryngology, First Affiliated Hospital of Medical College, 
      Zhejiang University, Hangzhou 310003, China. yzzhz@yzcn.net
FAU - Lin, Shan
AU  - Lin S
FAU - Wang, Shenqing
AU  - Wang S
FAU - Dai, Libo
AU  - Dai L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Aged
MH  - Apoptosis
MH  - Carcinoma, Squamous Cell/blood supply/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/blood supply/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Vascular Endothelial Growth Factor A/metabolism
EDAT- 2007/02/09 09:00
MHDA- 2011/04/08 06:00
CRDT- 2007/02/09 09:00
PHST- 2007/02/09 09:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
PHST- 2007/02/09 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Dec;20(23):1082-4.