PMID- 17287994
OWN - NLM
STAT- MEDLINE
DCOM- 20071017
LR  - 20220716
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 179
IP  - 4
DP  - 2007 Jun
TI  - Placebo analgesia: a PET study.
PG  - 655-64
AB  - Placebo analgesia involves complex mechanisms and sometimes has a marked effect 
      on patients in pain. In this study we examined changes in regional cerebral blood 
      flow (rCBF) under three different conditions (resting, hot, painful) before and 
      after placebo administration using H(2)(15)O and positron emission tomography in 
      ten healthy subjects. In five subjects, placebo administration significantly 
      decreased pain-intensity score (placebo responders), and rCBF in the medial 
      prefrontal cortex (MPFC), posterior parietal cortex (PPC), and inferior parietal 
      lobe (IPL) increased after placebo administration compared with before placebo 
      administration under the painful condition. Furthermore, in the placebo 
      responders, rCBF in the MPFC, PPC and IPL also increased under the resting 
      condition (without sensory stimulation) after placebo administration compared 
      with before placebo administration. However, there was no rCBF change under the 
      rest condition in the placebo nonresponders after placebo administration. These 
      results suggest that placebo analgesia has its effect under the resting condition 
      and MPFC, IPL and PPC may have an important role in placebo analgesia.
FAU - Nemoto, Hidenori
AU  - Nemoto H
AD  - Department of Anesthesiology, Mito Red Cross Hospital, 3-12-48 Sannomaru, Mito, 
      Ibaraki 310-0011, Japan. 2r5kq92w@384.jp
FAU - Nemoto, Yuki
AU  - Nemoto Y
FAU - Toda, Hikaru
AU  - Toda H
FAU - Mikuni, Masahiko
AU  - Mikuni M
FAU - Fukuyama, Hidenao
AU  - Fukuyama H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070208
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - 0 (Placebos)
SB  - IM
MH  - Adult
MH  - Analgesia/*psychology
MH  - Brain Mapping
MH  - Cerebral Cortex/anatomy & histology/diagnostic imaging/*physiology
MH  - Cerebrovascular Circulation/physiology
MH  - Female
MH  - Functional Laterality/physiology
MH  - Humans
MH  - Male
MH  - Nerve Net/anatomy & histology/diagnostic imaging/physiology
MH  - Neural Pathways/anatomy & histology/diagnostic imaging/physiology
MH  - Pain/*physiopathology/psychology
MH  - Pain Measurement
MH  - Pain Threshold/*physiology
MH  - Parietal Lobe/anatomy & histology/diagnostic imaging/physiology
MH  - Physical Stimulation
MH  - *Placebo Effect
MH  - Placebos/*pharmacology
MH  - Positron-Emission Tomography
MH  - Prefrontal Cortex/anatomy & histology/diagnostic imaging/physiology
EDAT- 2007/02/09 09:00
MHDA- 2007/10/18 09:00
CRDT- 2007/02/09 09:00
PHST- 2006/08/31 00:00 [received]
PHST- 2006/11/29 00:00 [accepted]
PHST- 2007/02/09 09:00 [pubmed]
PHST- 2007/10/18 09:00 [medline]
PHST- 2007/02/09 09:00 [entrez]
AID - 10.1007/s00221-006-0821-z [doi]
PST - ppublish
SO  - Exp Brain Res. 2007 Jun;179(4):655-64. doi: 10.1007/s00221-006-0821-z. Epub 2007 
      Feb 8.