PMID- 17288808
OWN - NLM
STAT- MEDLINE
DCOM- 20080505
LR  - 20111117
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 86
IP  - 42
DP  - 2006 Nov 14
TI  - [Polymorphism of human leukocyte antigen-A, B, and DRB1 genes in bone marrow 
      registry donors of Shaanxi province analysis of 14 006 cases].
PG  - 2971-4
AB  - OBJECTIVE: To analyze the polymorphism of human leukocyte antigen(HLA)-A, B, and 
      DRB1 genes in Shaanxi province, China. METHODS: Peripheral blood samples were 
      collected from 14 006 unrelated healthy voluntary bone marrow registry donors on 
      Shaanxi province, aged 18 - 45, with a male to female ratio of nearly 1:1. 
      Polymerase chain reaction sequence specific primer (PCR-SSP), polymerase chain 
      reaction sequence specific oligonucleotide probes (PCR-SSO), and sequencing-based 
      test (SBT) was used to analyze the polymorphism of HLA-A, B, and DRB1 genes. 
      RESULTS: In these 14 006 unrelated donors, 18, 40 and 15 HLA alleles were 
      identified on the HLA-A, B, and DRB1 loci respectively, including HLA-A25, B42, 
      B53, B73, and DR3 that were rarely reported in Han population. The gene 
      frequencies of HLA-A*02, A*11, A*24, A*33, B*13, B*46, B*4001 group (B60), B*1501 
      group (B62), DRB1*15, DRB1*09, DRB1*04, and DRB1*12 were all significantly higher 
      in the Shaanxi population. Two novel alleles were identified and officially 
      assigned by the WHO Nomenclature Committee as A*0290 and B*4814. CONCLUSION: The 
      characteristics of the polymorphism of HLA-A, B, and DRB1 genes in Shaanxi 
      province were established which will be helpful for patients to find matched 
      donors and establish the foundation for further studying population genetics and 
      HLA-related diseases.
FAU - Liu, Meng-li
AU  - Liu ML
AD  - Blood Center of Shaanxi Province, Xi'an 710061, China.
FAU - Qi, Jun
AU  - Qi J
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Liu, Sheng
AU  - Liu S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*25 antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Blood Donors/*statistics & numerical data
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - *Hematopoietic Stem Cells
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Registries/statistics & numerical data
EDAT- 2007/02/10 09:00
MHDA- 2008/05/06 09:00
CRDT- 2007/02/10 09:00
PHST- 2007/02/10 09:00 [pubmed]
PHST- 2008/05/06 09:00 [medline]
PHST- 2007/02/10 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2006 Nov 14;86(42):2971-4.