PMID- 17288951
OWN - NLM
STAT- MEDLINE
DCOM- 20070322
LR  - 20151119
IS  - 1579-2242 (Electronic)
IS  - 0300-8932 (Linking)
VI  - 60
IP  - 1
DP  - 2007 Jan
TI  - [Clinical significance of late gadolinium enhancement on cardiovascular magnetic 
      resonance in patients with hypertrophic cardiomyopathy].
PG  - 15-23
AB  - INTRODUCTION AND OBJECTIVES: In patients with hypertrophic cardiomyopathy, 
      myocardial fibrosis can be detected by late gadolinium enhancement (LGE) on 
      cardiac magnetic resonance imaging. We investigated the relationships between the 
      extent of LGE, left ventricular morphology and function, and clinical 
      characteristics. METHODS: Both cine and gadolinium-enhanced magnetic resonance 
      imaging were performed in 104 patients with hypertrophic cardiomyopathy. RESULTS: 
      Fifty patients (48%) showed LGE (range: 1-11 segments). The extent of LGE was 
      positively correlated with maximum left ventricular wall thickness (r=0.53, P< 
      .001), left ventricular mass (r=0.41, P< .001), and the number of hypokinetic 
      segments (r=0.51, P< .001), and inversely correlated with ejection fraction 
      (r=-0.32, P=.001), the magnitude of the subaortic gradient increase during 
      exercise echocardiography (r=-0.26, P=.023), and age at diagnosis (r=-0.20, 
      P=.04). Four of the five patients with an ischemic response on exercise 
      echocardiography had > or =3 segments showing LGE (P=.003). Severe hypertrophy 
      (i.e., > or =30 mm) and nonsustained ventricular tachycardia occurred more 
      frequently as the number of LGE segments increased (P< .001 and P=.04, 
      respectively). CONCLUSIONS: Extensive LGE reflects greater disease expression. It 
      is associated with more severe myocardial damage (i.e., a lower ejection fraction 
      and a larger number of hypokinetic segments) and with adverse clinical 
      characteristics (e.g., young age at diagnosis, severe hypertrophy, nonsustained 
      ventricular tachycardia, and an ischemic response on exercise), suggesting that 
      it may be closely linked to prognosis.
FAU - Dumont, Carlos A
AU  - Dumont CA
AD  - Servicio de Cardiologia, Hospital Juan Canalejo, A Coruna, Spain.
FAU - Monserrat, Lorenzo
AU  - Monserrat L
FAU - Soler, Rafaela
AU  - Soler R
FAU - Rodriguez, Esther
AU  - Rodriguez E
FAU - Fernandez, Xusto
AU  - Fernandez X
FAU - Peteiro, Jesus
AU  - Peteiro J
FAU - Bouzas, Beatriz
AU  - Bouzas B
FAU - Pinon, Pablo
AU  - Pinon P
FAU - Castro-Beiras, Alfonso
AU  - Castro-Beiras A
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Significado clinico del realce tardio de gadolinio con resonancia magnetica en 
      pacientes con miocardiopatia hipertrofica.
PL  - Spain
TA  - Rev Esp Cardiol
JT  - Revista espanola de cardiologia
JID - 0404277
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
CIN - Rev Esp Cardiol. 2007 Jan;60(1):1-4. PMID: 17288947
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*diagnosis/pathology/physiopathology
MH  - Chi-Square Distribution
MH  - Child
MH  - *Contrast Media
MH  - Death, Sudden, Cardiac/etiology
MH  - Echocardiography, Stress/methods
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Hypertrophy, Left Ventricular/pathology/physiopathology
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Prognosis
MH  - Regression Analysis
MH  - Risk Factors
MH  - Stroke Volume/physiology
MH  - Ventricular Dysfunction, Left/physiopathology
EDAT- 2007/02/10 09:00
MHDA- 2007/03/23 09:00
CRDT- 2007/02/10 09:00
PHST- 2007/02/10 09:00 [pubmed]
PHST- 2007/03/23 09:00 [medline]
PHST- 2007/02/10 09:00 [entrez]
AID - 13097921 [pii]
PST - ppublish
SO  - Rev Esp Cardiol. 2007 Jan;60(1):15-23.