PMID- 17289056
OWN - NLM
STAT- MEDLINE
DCOM- 20070725
LR  - 20191210
IS  - 0021-9673 (Print)
IS  - 0021-9673 (Linking)
VI  - 1153
IP  - 1-2
DP  - 2007 Jun 15
TI  - Multiresidue analysis of pesticides in animal liver by gas chromatography using 
      triple quadrupole tandem mass spectrometry.
PG  - 194-202
AB  - Two methods for extracting organochlorine (OCs) and organophosphorus (OPs) 
      pesticides from animal liver have been developed. The determination was carried 
      out by gas chromatography with electron impact ionization tandem mass 
      spectrometry (GC-(EI-)MS/MS) using a triple quadrupole (QqQ) analyzer. First, a 
      liquid-solid extraction performed with a high-speed homogenizer (Polytron) using 
      ethyl acetate as solvent, and a subsequent clean-up by gel permeation 
      chromatography (GPC) was applied, determining 34 pesticides. Secondly, a matrix 
      solid phase dispersion (MSPD) extraction with octadecylsilyl (C(18)) sorbent 
      combined with a Florisil clean-up and ethyl acetate elution was performed, 
      analyzing 25 compounds. These methodologies have been tested and compared in the 
      sample pre-treatment due to the fatty nature of the matrix. The GPC method was 
      finally selected and validated, yielding recoveries in the range 70-115%, with 
      precision values expressed as relative standard deviation (RSD) lower or equal to 
      20%, at the spiking levels of 25 and 50 microg kg(-1), and limits of 
      quantification (LOQs) lower than the maximum residue levels (MRLs) set by the 
      European Union in animal products, except for isofenphos. Linearity was also 
      studied ranging between 5 and 300 microg kg(-1) for most of pesticides. This 
      method was applied to the analysis of real liver samples of chicken, pork and 
      lamb.
FAU - Frenich, Antonia Garrido
AU  - Frenich AG
AD  - Analytical Chemistry of Pollutants Research Group (ISO 9001 Certificate), 
      Department of Analytical Chemistry, University of Almeria, 04120 Almeria, Spain. 
      agarrido@ual.es
FAU - Bolanos, Patricia Plaza
AU  - Bolanos PP
FAU - Vidal, Jose Luis Martinez
AU  - Vidal JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20070207
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Hydrocarbons, Halogenated)
RN  - 0 (Pesticide Residues)
RN  - OKA6A6ZD4K (Endosulfan)
SB  - IM
MH  - Analytic Sample Preparation Methods
MH  - Animals
MH  - Chickens
MH  - Chromatography, Gel
MH  - Endosulfan/analysis
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Hydrocarbons, Halogenated/analysis
MH  - Liver/*chemistry
MH  - Pesticide Residues/*analysis
MH  - Sheep
MH  - Sus scrofa
MH  - Tandem Mass Spectrometry/*methods
MH  - Uncertainty
EDAT- 2007/02/10 09:00
MHDA- 2007/07/26 09:00
CRDT- 2007/02/10 09:00
PHST- 2006/09/25 00:00 [received]
PHST- 2007/01/15 00:00 [revised]
PHST- 2007/01/19 00:00 [accepted]
PHST- 2007/02/10 09:00 [pubmed]
PHST- 2007/07/26 09:00 [medline]
PHST- 2007/02/10 09:00 [entrez]
AID - S0021-9673(07)00145-8 [pii]
AID - 10.1016/j.chroma.2007.01.066 [doi]
PST - ppublish
SO  - J Chromatogr A. 2007 Jun 15;1153(1-2):194-202. doi: 10.1016/j.chroma.2007.01.066. 
      Epub 2007 Feb 7.