PMID- 17289084
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20220317
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 80
IP  - 13
DP  - 2007 Mar 6
TI  - Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation 
      in experimental diabetic neuropathy.
PG  - 1236-44
AB  - Oxidative stress has been implicated in pathophysiology of diabetic neuropathy. 
      All the pathways responsible for development of diabetic neuropathy are linked to 
      oxidative stress in one way or the other. In the present study, we have targeted 
      oxidative stress in diabetic neuropathy using resveratrol, a potent antioxidant. 
      Eight weeks streptozotocin-diabetic rats developed neuropathy which was evident 
      from significant reduction in motor nerve conduction velocity (MNCV), nerve blood 
      flow (NBF) and increased thermal hyperalgesia. The 2-week treatment with 
      resveratrol (10 and 20 mg/kg, i.p.) started 6 weeks after diabetes induction 
      significantly ameliorated the alterations in MNCV, NBF, and hyperalgesia. 
      Resveratrol also attenuated enhanced levels of malondialdehyde (MDA), 
      peroxynitrite and produced increase in catalase levels in diabetic rats. There 
      was marked reduction in DNA fragmentation observed after resveratrol treatment in 
      diabetic rats as evident from decrease in Terminal deoxynucleotidyl 
      transferase-mediated dUTP nick end labeling (TUNEL) positive cells in sciatic 
      nerve sections. Results of the present study suggest the potential of resveratrol 
      in treatment of diabetic neuropathy and its protective effect may be mediated 
      through reduction in oxidative stress and DNA fragmentation.
FAU - Kumar, Ashutosh
AU  - Kumar A
AD  - Molecular Neuropharmacology Laboratory, Department of Pharmacology and 
      Toxicology, National Institute of Pharmaceutical Education and Research, 
      Sector-67, S.A.S. Nagar, Punjab-160062, India.
FAU - Kaundal, Ravinder K
AU  - Kaundal RK
FAU - Iyer, Seethalakshmi
AU  - Iyer S
FAU - Sharma, Shyam S
AU  - Sharma SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070120
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Stilbenes)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antioxidants/*therapeutic use
MH  - Apoptosis/drug effects
MH  - Blood Glucose/analysis
MH  - DNA Fragmentation/*drug effects
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism/physiopathology
MH  - Diabetic Neuropathies/*drug therapy/metabolism/physiopathology
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - In Situ Nick-End Labeling
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Neural Conduction/*drug effects
MH  - Oxidative Stress/*drug effects
MH  - Pain Measurement
MH  - Pain Threshold/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Regional Blood Flow/drug effects
MH  - Resveratrol
MH  - Sciatic Nerve/blood supply/*drug effects/pathology/physiopathology
MH  - Stilbenes/*therapeutic use
EDAT- 2007/02/10 09:00
MHDA- 2007/03/30 09:00
CRDT- 2007/02/10 09:00
PHST- 2006/08/05 00:00 [received]
PHST- 2006/11/22 00:00 [revised]
PHST- 2006/12/20 00:00 [accepted]
PHST- 2007/02/10 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2007/02/10 09:00 [entrez]
AID - S0024-3205(07)00025-2 [pii]
AID - 10.1016/j.lfs.2006.12.036 [doi]
PST - ppublish
SO  - Life Sci. 2007 Mar 6;80(13):1236-44. doi: 10.1016/j.lfs.2006.12.036. Epub 2007 
      Jan 20.