PMID- 17289348
OWN - NLM
STAT- MEDLINE
DCOM- 20070612
LR  - 20160526
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 91
IP  - 1-3
DP  - 2007 Mar
TI  - Brain-derived neurotrophic factor gene C-270T and Val66Met functional 
      polymorphisms and risk of schizophrenia: a moderate-scale population-based study 
      and meta-analysis.
PG  - 6-13
AB  - BACKGROUND: Lines of evidence have suggested that the brain-derived neurotrophic 
      factor (BDNF) gene may be involved in the pathogenesis of schizophrenia. Two 
      common functional polymorphisms C-270T and Val66Met within the BDNF gene were 
      first reported by Kunugi et al. [Kunugi, H., Nanko, S., Hirasawa, H., Kato, N., 
      Nabika, T., Kobayashi, S., 2003. Brain-derived neurotrophic factor gene and 
      schizophrenia: polymorphism screening and association analysis. Schizophr. Res. 
      62, 281-283.] and pls expand this too: Hong et al. (2003) to be significantly 
      associated with schizophrenia. However, subsequently several studies obtained 
      conflicting results. METHODS: We compared the allele/genotype frequencies of the 
      C-270T and Val66Met polymorphisms and the haplotype frequencies at the two 
      polymorphisms in a moderate independent patient-control sample from the Han 
      Chinese population. Two systematic meta-analyses were performed to assess the 
      collective evidence for association across studies for each of the two 
      polymorphisms. RESULTS: No statistically significant differences were found in 
      allele or genotype or haplotype frequencies between patient and normal control 
      subjects for either of the two polymorphisms. On the other hand, the 
      meta-analysis of all published population-based association studies showed 
      statistically significant evidence for heterogeneity among each of the two 
      polymorphisms. Stratification of the studies by ethnicity of the samples yielded 
      no significant evidence for an association with the polymorphisms in the 
      Caucasian population (for C-270T polymorphism: pooled OR(Caucasian)=0.736, 95% 
      CI=0.476-1.139, p=0.169; for Val66Met polymorphism: pooled OR(Caucasian)=1.027, 
      95% CI=0.796-1.325, p=0.835), nor in the Asian population (for C-270T 
      polymorphism: pooled OR(Asian)=0.445, 95% CI=0.144-1.373, p=0.159; for Val66Met 
      polymorphism: pooled OR(Asian)=0.962, 95% CI=0.820-1.128, p=0.635). CONCLUSIONS: 
      Our population-based study and meta-analysis demonstrate that the BDNF C-270T and 
      Val66Met polymorphisms do not play major roles in the susceptibility to 
      schizophrenia in either Caucasian or Asian populations. But we can not rule out 
      the possibility that other polymorphisms with the BDNF gene are involved in the 
      pathophysiology of schizophrenia.
FAU - Xu, Ming-Qing
AU  - Xu MQ
AD  - Bio-X Centre, Shanghai Jiao Tong University, Shanghai 200030, PR China.
FAU - St Clair, David
AU  - St Clair D
FAU - Ott, Jurg
AU  - Ott J
FAU - Feng, Guo-Yin
AU  - Feng GY
FAU - He, Lin
AU  - He L
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20070207
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Gene Expression/*genetics
MH  - Genomics
MH  - Genotype
MH  - Haplotypes/genetics
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Mass Screening
MH  - Polymorphism, Genetic/*genetics
MH  - Population Surveillance/methods
MH  - Risk Factors
MH  - Schizophrenia/*genetics/*physiopathology
EDAT- 2007/02/10 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/02/10 09:00
PHST- 2006/04/13 00:00 [received]
PHST- 2006/12/06 00:00 [revised]
PHST- 2006/12/07 00:00 [accepted]
PHST- 2007/02/10 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/02/10 09:00 [entrez]
AID - S0920-9964(06)00515-9 [pii]
AID - 10.1016/j.schres.2006.12.008 [doi]
PST - ppublish
SO  - Schizophr Res. 2007 Mar;91(1-3):6-13. doi: 10.1016/j.schres.2006.12.008. Epub 
      2007 Feb 7.