PMID- 17289378
OWN - NLM
STAT- MEDLINE
DCOM- 20070511
LR  - 20081121
IS  - 0960-0760 (Print)
IS  - 0960-0760 (Linking)
VI  - 103
IP  - 3-5
DP  - 2007 Mar
TI  - Exons and functional regions of the human vitamin D receptor gene around and 
      within the main 1a promoter are well conserved among mammals.
PG  - 361-7
AB  - The human vitamin D receptor (hVDR) gene encompasses eight exons (2-9) in the 
      so-called coding region and six more exons (1a-1f) in the so-called regulatory 
      region, which contains several reported promoters. Evolutionary comparison 
      performed on the VDR promoter sequences of a dozen of mammalian species shows a 
      very high conservation of numerous regions around and in the 1a promoter, 
      including exons 1e, 1a and 1d, and the Sp1 site region. This suggests that the 
      so-called 1a promoter is well conserved among mammals. Homology among mammals 
      also concerns three functional SNP site regions of the hVDR 1a promoter, the 
      1e-G-1739A SNP region (a Cdx-2 binding site), and both 1a-G-1521C and 1a-A-1012G 
      sites, the 1a-1012A being located within a GATA site. Interestingly, the 1521G 
      and 1012A nucleotides are being evolutionary conserved, suggesting that the 
      1521C/1012G haplotype, which is found in human chromosomes (43% of Caucasians), 
      is a human specificity.
FAU - Jehan, Frederic
AU  - Jehan F
AD  - INSERM U561, Hopital Saint Vincent de Paul, 82 Avenue Denfert-Rochereau, 75014 
      Paris, France. jehan@paris5.inserm.fr
FAU - d'Alesio, Arnold
AU  - d'Alesio A
FAU - Garabedian, Michele
AU  - Garabedian M
LA  - eng
PT  - Journal Article
DEP - 20070206
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - 0 (Receptors, Calcitriol)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Conserved Sequence
MH  - Evolution, Molecular
MH  - Exons/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Promoter Regions, Genetic/*genetics
MH  - Receptors, Calcitriol/*genetics
EDAT- 2007/02/10 09:00
MHDA- 2007/05/12 09:00
CRDT- 2007/02/10 09:00
PHST- 2006/11/30 00:00 [received]
PHST- 2007/02/10 09:00 [pubmed]
PHST- 2007/05/12 09:00 [medline]
PHST- 2007/02/10 09:00 [entrez]
AID - S0960-0760(06)00435-3 [pii]
AID - 10.1016/j.jsbmb.2006.12.057 [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):361-7. doi: 
      10.1016/j.jsbmb.2006.12.057. Epub 2007 Feb 6.