PMID- 17290441
OWN - NLM
STAT- MEDLINE
DCOM- 20070529
LR  - 20080521
IS  - 1552-4868 (Print)
IS  - 1552-4868 (Linking)
VI  - 145C
IP  - 1
DP  - 2007 Feb 15
TI  - Molecular cytogenetic and rapid aneuploidy detection methods in prenatal 
      diagnosis.
PG  - 87-98
AB  - Cytogenetic analysis is an important component of prenatal diagnosis. The ability 
      to rapidly detect aneuploidy and identify small structural abnormalities of fetal 
      chromosomes has been greatly enhanced by the use of molecular cytogenetic 
      technologies. In this review, we will present some of the molecular cytogenetic 
      techniques available to the clinical cytogenetics laboratory. These include 
      fluorescence in situ hybridization (FISH), quantitative fluorescence PCR 
      (QF-PCR), multiplex ligation-dependent probe amplification (MLPA) and 
      microarray-based comparative genomic hybridization (array CGH). The benefits and 
      limitations of each technology will be discussed in the context of prenatal 
      diagnosis.
CI  - (c) 2007 Wiley-Liss, Inc.
FAU - Shaffer, Lisa G
AU  - Shaffer LG
AD  - Signature Genomic Laboratories, Spokane, WA 99202, USA. 
      shaffer@signaturegenomics.com
FAU - Bui, The-Hung
AU  - Bui TH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Am J Med Genet C Semin Med Genet
JT  - American journal of medical genetics. Part C, Seminars in medical genetics
JID - 101235745
SB  - IM
MH  - *Aneuploidy
MH  - *Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Microarray Analysis
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
RF  - 117
EDAT- 2007/02/10 09:00
MHDA- 2007/05/30 09:00
CRDT- 2007/02/10 09:00
PHST- 2007/02/10 09:00 [pubmed]
PHST- 2007/05/30 09:00 [medline]
PHST- 2007/02/10 09:00 [entrez]
AID - 10.1002/ajmg.c.30114 [doi]
PST - ppublish
SO  - Am J Med Genet C Semin Med Genet. 2007 Feb 15;145C(1):87-98. doi: 
      10.1002/ajmg.c.30114.