PMID- 17290445
OWN - NLM
STAT- MEDLINE
DCOM- 20070830
LR  - 20200930
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 144B
IP  - 5
DP  - 2007 Jul 5
TI  - Association study of dysbindin gene with clinical and outcome measures in a 
      representative cohort of Italian schizophrenic patients.
PG  - 647-59
AB  - There is evidence suggesting that Dysbindin (DTNBP1) is a susceptibility gene for 
      schizophrenia in Caucasian, Chinese, and Japanese populations. We sought to 
      determine if dysbindin was associated with schizophrenia and its symptoms in a 
      representative group of schizophrenic patients from a Community-Based Mental 
      Health Service (CMHS) in Verona, Italy. A prevalence cohort of schizophrenic 
      patients (n = 141) was assessed at baseline and then 3 and 6 years later. Eighty 
      patients and 106 healthy controls were genotyped for polymorphisms in dysbindin. 
      We tested if diagnosis, clinical symptoms as measured by the Brief Psychiatric 
      Rating Scale (BPRS), and functioning as measured by the Global Assessment of 
      Functioning Scale (GAF), were associated with the presence of certain dysbindin 
      polymorphisms. Finally, using the longitudinal clinical data, we tested if 
      patients carrying dysbindin high-risk haplotypes had a more unfavorable 
      longitudinal clinical outcome. A trend towards statistical association (P = 
      0.058) between schizophrenia and rs2619538 was found. Using GENECOUNTING 
      software, we found that rs2619538-P1583 (P = 0.048), P1320-P1757 (P = 0.034), and 
      rs2619538-P1583-P1578 (P = 0.040) haplotypes occurred more often in cases 
      compared to controls before correction for multiple testing. The rs2619538-P1583 
      haplotype was more likely to be transmitted to subjects with more severe and 
      persistent psychopathology. These preliminary results are compatible with the 
      view that DTNBP1 is a susceptibility factor for schizophrenia, and is associated 
      with worse psychopathology.
FAU - Tosato, Sarah
AU  - Tosato S
AD  - Section of Psychiatry and Clinical Psychology, University of Verona, Verona, 
      Italy. sarah.tosato@univr.it
FAU - Ruggeri, Mirella
AU  - Ruggeri M
FAU - Bonetto, Chiara
AU  - Bonetto C
FAU - Bertani, Mariaelena
AU  - Bertani M
FAU - Marrella, Giovanna
AU  - Marrella G
FAU - Lasalvia, Antonio
AU  - Lasalvia A
FAU - Cristofalo, Doriana
AU  - Cristofalo D
FAU - Aprili, Giuseppe
AU  - Aprili G
FAU - Tansella, Michele
AU  - Tansella M
FAU - Dazzan, Paola
AU  - Dazzan P
FAU - Diforti, Marta
AU  - Diforti M
FAU - Murray, Robin M
AU  - Murray RM
FAU - Collier, David A
AU  - Collier DA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Carrier Proteins)
RN  - 0 (DTNBP1 protein, human)
RN  - 0 (Dysbindin)
RN  - 0 (Dystrophin-Associated Proteins)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Carrier Proteins/*genetics
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Dysbindin
MH  - Dystrophin-Associated Proteins
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - *Haplotypes
MH  - Humans
MH  - Interview, Psychological
MH  - Italy/epidemiology
MH  - Longitudinal Studies
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Schizophrenia/epidemiology/*genetics
EDAT- 2007/02/10 09:00
MHDA- 2007/08/31 09:00
CRDT- 2007/02/10 09:00
PHST- 2007/02/10 09:00 [pubmed]
PHST- 2007/08/31 09:00 [medline]
PHST- 2007/02/10 09:00 [entrez]
AID - 10.1002/ajmg.b.30484 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144B(5):647-59. doi: 
      10.1002/ajmg.b.30484.