PMID- 172912 OWN - NLM STAT- MEDLINE DCOM- 19760219 LR - 20190501 IS - 0027-8424 (Print) IS - 1091-6490 (Electronic) IS - 0027-8424 (Linking) VI - 72 IP - 11 DP - 1975 Nov TI - Relationship in nucleic acid sequences between mouse mammary tumor virus variants. PG - 4635-9 AB - Primary cultures of mouse mammary carcinomas were used as a source of both radioactively labeled and unlabeled 60-70S RNA of mouse mammary tumor virus (MMTV) obtained from various mouse strains. Competition molecular hybridization experiments revealed that, within the limits of the assay, the RNAs of the MMTVs synthesized in culture by the tumors of the mouse strains RIII, GR, A, and C3H, are identical. A comparison of the genomes of the milk-transmitted MMTV(C3H) and the vertically transmitted MMTV(C3Hf) revealed that these two viruses are approximately 75% similar. No nucleic acid sequence homology was observed between MMTV(C3H) 60-70S RNA and the RNAs of murine leukemia virus, Mason-Pfizer virus, or the BrdUrd-induced type-B quinea pig virus. FAU - Michalides, R AU - Michalides R FAU - Schlom, J AU - Schlom J LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Proc Natl Acad Sci U S A JT - Proceedings of the National Academy of Sciences of the United States of America JID - 7505876 RN - 0 (RNA, Viral) SB - IM MH - Animals MH - Mammary Tumor Virus, Mouse/*analysis MH - Mice MH - Nucleic Acid Hybridization MH - RNA, Viral/*analysis MH - Species Specificity PMC - PMC388778 EDAT- 1975/11/01 00:00 MHDA- 1975/11/01 00:01 PMCR- 1976/05/01 CRDT- 1975/11/01 00:00 PHST- 1975/11/01 00:00 [pubmed] PHST- 1975/11/01 00:01 [medline] PHST- 1975/11/01 00:00 [entrez] PHST- 1976/05/01 00:00 [pmc-release] AID - 10.1073/pnas.72.11.4635 [doi] PST - ppublish SO - Proc Natl Acad Sci U S A. 1975 Nov;72(11):4635-9. doi: 10.1073/pnas.72.11.4635.