PMID- 17291737
OWN - NLM
STAT- MEDLINE
DCOM- 20080207
LR  - 20131121
IS  - 0944-7113 (Print)
IS  - 0944-7113 (Linking)
VI  - 14
IP  - 12
DP  - 2007 Dec
TI  - Annona squamosa seed extract in the regulation of hyperthyroidism and 
      lipid-peroxidation in mice: possible involvement of quercetin.
PG  - 799-805
AB  - Annona squamosa (Custard apple) seeds are generally thrown away as waste 
      materials. The extract of these seeds was evaluated for its possible ameliorative 
      effect in the regulation of hyperthyroidism in mouse model. Serum 
      triiodothyronine (T(3)), thyroxine (T(4)) concentrations, hepatic 
      glucose-6-phospatase (G-6-Pase) and 5'-mono-deiodinase (5'DI) activity were 
      considered as the end parameters of thyroid function. Simultaneously hepatic 
      lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) 
      activities were investigated to observe its hepatotoxic effect, if any. L-T(4) 
      administration (0.5 mg/kg/d for 12 days, i.p.) increased the levels of serum T(3) 
      and T(4), activity of hepatic G-6-Pase, 5'DI and LPO with a parallel decrease in 
      SOD and CAT activities. However, simultaneous administration of the Annona seed 
      extract (200 mg/kg) or quercetin (10 mg/kg) to T(4)-induced hyperthyroid animals 
      for 10 days, reversed all these effects indicating their potential in the 
      regulation of hyperthyroidism. Further, the seed extract did not increase, but 
      decreased the hepatic LPO suggesting its safe and antiperoxidative nature. 
      Quercetin also decreased hepatic LPO. When relative efficacy was compared with 
      that of propyl thiouracil (PTU), a standard antithyroidic drug, experimental seed 
      extract appeared to be more effective. Phytochemical analyses including HPLC 
      revealed the presence of quercetin in the seed extract and the results on the 
      effects of quercetin suggested the involvement of this phytochemical in the 
      mediation of antithyroidal activity of Annona squamosa seed extract.
FAU - Panda, S
AU  - Panda S
AD  - Thyroid Research Laboratory, School of Life Sciences (Annex), Devi Ahilya 
      University, Vigyan Bhawan, Takhshila Campus, Khandwa Road, Indore 452017, Madhya 
      Pradesh, India.
FAU - Kar, A
AU  - Kar A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070208
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Plant Extracts)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9IKM0I5T1E (Quercetin)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 3.1.3.9 (Glucose-6-Phosphatase)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Annona/*embryology
MH  - Catalase/blood
MH  - Chromatography, High Pressure Liquid
MH  - Female
MH  - Glucose-6-Phosphatase/blood
MH  - Hyperthyroidism/*drug therapy
MH  - Lipid Peroxidation/*drug effects
MH  - Mice
MH  - Plant Extracts/*pharmacology/therapeutic use
MH  - Quercetin/*pharmacology/therapeutic use
MH  - Seeds/*chemistry
MH  - Superoxide Dismutase/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
EDAT- 2007/02/13 09:00
MHDA- 2008/02/08 09:00
CRDT- 2007/02/13 09:00
PHST- 2007/02/13 09:00 [pubmed]
PHST- 2008/02/08 09:00 [medline]
PHST- 2007/02/13 09:00 [entrez]
AID - S0944-7113(06)00216-9 [pii]
AID - 10.1016/j.phymed.2006.12.001 [doi]
PST - ppublish
SO  - Phytomedicine. 2007 Dec;14(12):799-805. doi: 10.1016/j.phymed.2006.12.001. Epub 
      2007 Feb 8.