PMID- 17292620
OWN - NLM
STAT- MEDLINE
DCOM- 20070829
LR  - 20150831
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 55
IP  - 4
DP  - 2007 Apr
TI  - FeTPPS protects against global cerebral ischemic-reperfusion injury in gerbils.
PG  - 335-42
AB  - Neuronal damage following cerebral ischemia is mediated by various mechanisms, 
      among which nitrosative stress plays an important role. Peroxynitrite, a powerful 
      oxidant, contributes heavily to the neuronal damage in cerebral 
      ischemic-reperfusion (IR) injury. In the present study, we have investigated the 
      neuroprotective effects of a peroxynitrite decomposition catalyst, 
      5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrinato iron(III) [FeTPPS] in global 
      cerebral IR injury in gerbils. Neurological damage was significantly attenuated 
      by FeTPPS treatment (1 and 3mgkg(-1), i.p.) as evident from reduction in 
      neurological symptoms, hyperlocomotion, memory impairment and CA1 hippocampal 
      neuronal damage in IR challenged gerbils. FeTPPS treatment also attenuated the 
      increased malondialdehyde (MDA) levels and terminal deoxynucleotidyl 
      transferase-mediated dUTP nick end labeling (TUNEL) positive cells after cerebral 
      IR injury. Results of this study demonstrates the neuroprotective activity of 
      FeTPPS in global cerebral IR injury and its neuroprotective effects may be 
      attributed to reduction in oxidative stress and DNA fragmentation.
FAU - Sharma, Shyam S
AU  - Sharma SS
AD  - Department of Pharmacology and Toxicology, National Institute of Pharmaceutical 
      Education and Research (NIPER), Sector-67, S.A.S. Nagar, Punjab 160062, India. 
      sssharma@niper.ac.in
FAU - Dhar, Arti
AU  - Dhar A
FAU - Kaundal, Ravinder K
AU  - Kaundal RK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070116
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride)
RN  - 0 (Metalloporphyrins)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Behavior, Animal/drug effects
MH  - Brain Ischemia/*complications/drug therapy/pathology/physiopathology
MH  - Carotid Artery, Common/surgery
MH  - DNA Fragmentation/*drug effects
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Gerbillinae
MH  - Hippocampus/*drug effects/pathology/physiopathology
MH  - In Situ Nick-End Labeling
MH  - Learning/drug effects
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Memory/drug effects
MH  - Metalloporphyrins/*pharmacology/therapeutic use
MH  - Motor Activity/drug effects
MH  - Neuroprotective Agents/*pharmacology/therapeutic use
MH  - Oxidative Stress/*drug effects
MH  - Reaction Time/drug effects
MH  - Reperfusion Injury/etiology/pathology/physiopathology/*prevention & control
EDAT- 2007/02/13 09:00
MHDA- 2007/08/30 09:00
CRDT- 2007/02/13 09:00
PHST- 2006/08/05 00:00 [received]
PHST- 2006/12/13 00:00 [revised]
PHST- 2007/01/08 00:00 [accepted]
PHST- 2007/02/13 09:00 [pubmed]
PHST- 2007/08/30 09:00 [medline]
PHST- 2007/02/13 09:00 [entrez]
AID - S1043-6618(07)00016-3 [pii]
AID - 10.1016/j.phrs.2007.01.002 [doi]
PST - ppublish
SO  - Pharmacol Res. 2007 Apr;55(4):335-42. doi: 10.1016/j.phrs.2007.01.002. Epub 2007 
      Jan 16.