PMID- 17292721
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20220408
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 56
IP  - 3
DP  - 2007 Mar
TI  - An exercise intervention without weight loss decreases circulating interleukin-6 
      in lean and obese men with and without type 2 diabetes mellitus.
PG  - 332-8
AB  - Obesity and type 2 diabetes mellitus (T2DM) have been associated with a state of 
      chronic low-grade inflammation. We examined the effect of exercise without weight 
      loss on circulating inflammatory biomarkers in previously sedentary lean men and 
      obese men with and without T2DM. Middle-aged men (8 lean, 8 obese, and 8 obese 
      with T2DM) performed 60 minutes of aerobic exercise 5 times per week for 12 weeks 
      without a reduction in body weight. Subjects underwent a 
      hyperinsulinemic-euglycemic clamp before and after the 12-week exercise program 
      to assess insulin sensitivity. Circulating interleukin-6 (IL-6), plasminogen 
      activator inhibitor-1 (PAI-1), and C-reactive protein concentrations were 
      measured by sandwich enzyme-linked immunosorbent assay before and after the 
      exercise intervention. Body fat was measured using magnetic resonance imaging, 
      and waist circumference was recorded for each subject pre- and postexercise 
      intervention. Waist circumference and plasma IL-6 concentrations were 
      significantly lower (P < .05) after exercise training despite no change in body 
      weight or insulin sensitivity. There were no correlations between insulin 
      sensitivity and IL-6. Fasting plasma PAI-1 concentration was significantly lower 
      in the lean group compared with the obese group both pre- and postexercise 
      intervention (P < .05). There were no changes in C-reactive protein or PAI-1 
      concentrations after exercise training. A 12-week exercise intervention led to 
      reductions in waist circumference and fasting IL-6 concentrations in previously 
      sedentary lean and obese men with or without T2DM, demonstrating significant 
      changes in clinically relevant diabetes-related parameters despite no change in 
      body weight.
FAU - Dekker, Mark J
AU  - Dekker MJ
AD  - Department of Human Health and Nutritional Sciences, University of Guelph, 
      Guelph, Ontario, Canada N1G 2W1.
FAU - Lee, SoJung
AU  - Lee S
FAU - Hudson, Robert
AU  - Hudson R
FAU - Kilpatrick, Katherine
AU  - Kilpatrick K
FAU - Graham, Terry E
AU  - Graham TE
FAU - Ross, Robert
AU  - Ross R
FAU - Robinson, Lindsay E
AU  - Robinson LE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Interleukin-6)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adiposity
MH  - Adult
MH  - C-Reactive Protein/analysis
MH  - Diabetes Mellitus, Type 2/*blood
MH  - *Exercise
MH  - Fasting
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Intra-Abdominal Fat/metabolism
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood
MH  - Plasminogen Activator Inhibitor 1/blood
MH  - *Weight Loss
EDAT- 2007/02/13 09:00
MHDA- 2007/03/21 09:00
CRDT- 2007/02/13 09:00
PHST- 2006/06/08 00:00 [received]
PHST- 2006/10/03 00:00 [accepted]
PHST- 2007/02/13 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2007/02/13 09:00 [entrez]
AID - S0026-0495(06)00379-9 [pii]
AID - 10.1016/j.metabol.2006.10.015 [doi]
PST - ppublish
SO  - Metabolism. 2007 Mar;56(3):332-8. doi: 10.1016/j.metabol.2006.10.015.