PMID- 17292934
OWN - NLM
STAT- MEDLINE
DCOM- 20070720
LR  - 20211203
IS  - 0041-0101 (Print)
IS  - 0041-0101 (Linking)
VI  - 49
IP  - 6
DP  - 2007 May
TI  - The cyanobacterial toxin, cylindrospermopsin, induces fetal toxicity in the mouse 
      after exposure late in gestation.
PG  - 855-64
AB  - Cylindrospermopsin (cyn) is a cyanobacterial toxin implicated in human and 
      wildlife poisonings. We have completed studies investigating the potential of 
      purified cyn to induce developmental toxicity in mammals. The teratology study 
      involved intraperitoneal injections (8.0-128 microg kg(-1)) on gestational days 
      (GD) 8-12 with subsequent examination of term fetuses for viability, weight and 
      morphological anomalies. Cyn was lethal to a significant portion of the dams 
      receiving > or = 32 microg kg(-1). Surviving pregnant females were killed and 
      fetuses removed for examination. Analysis indicates no adverse effects on litter 
      size, fetal weight, or incidence of anomalies. Subsequently, 50 microg kg(-1) cyn 
      was administered on GD 8-12 or 13-17. Animals were allowed to give birth and 
      litters monitored for growth and viability. A reduction in litter size occurred 
      in treated groups. Avg. pup wt. was only affected in the GD 13-17 group. GD 13-17 
      dams did not exhibit the toxicity noted in the GD 8-12 group but gave birth 
      significantly earlier than controls. There was a significant number of dead GD 
      13-17 pups and incidences of blood in the gastrointestinal tract and hematomas in 
      the tips of the tails in survivors. Pups were cross-fostered to control mothers 
      in litters of 10. On postnatal days (PND) 5-6 there were no significant 
      differences in weight gain or viability in GD 8-12 litters, while GD 13-17 
      litters had significantly reduced weight gain and viability. GD 13-17 exposed 
      male pups still weighed significantly less than the controls after 15 months.
FAU - Rogers, E H
AU  - Rogers EH
AD  - US EPA, ORD, National Health and Environmental Effects Research Laboratory, 
      Research Triangle Park, NC 27711, USA.
FAU - Zehr, R D
AU  - Zehr RD
FAU - Gage, M I
AU  - Gage MI
FAU - Humpage, A R
AU  - Humpage AR
FAU - Falconer, I R
AU  - Falconer IR
FAU - Marr, M
AU  - Marr M
FAU - Chernoff, N
AU  - Chernoff N
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070105
PL  - England
TA  - Toxicon
JT  - Toxicon : official journal of the International Society on Toxinology
JID - 1307333
RN  - 0 (Alkaloids)
RN  - 0 (Bacterial Toxins)
RN  - 0 (Cyanobacteria Toxins)
RN  - 0 (Marine Toxins)
RN  - 0 (Microcystins)
RN  - 2JIZ556BA3 (cylindrospermopsin)
RN  - 56HH86ZVCT (Uracil)
SB  - IM
MH  - Alkaloids
MH  - Animals
MH  - Animals, Newborn
MH  - Bacterial Toxins/administration & dosage/*toxicity
MH  - *Cyanobacteria
MH  - Cyanobacteria Toxins
MH  - Embryo, Mammalian/drug effects
MH  - Female
MH  - Fetus/drug effects
MH  - Gestational Age
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Marine Toxins/administration & dosage/*toxicity
MH  - Mice
MH  - Microcystins/administration & dosage/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Uracil/administration & dosage/*analogs & derivatives/toxicity
EDAT- 2007/02/13 09:00
MHDA- 2007/07/21 09:00
CRDT- 2007/02/13 09:00
PHST- 2006/11/01 00:00 [received]
PHST- 2006/12/14 00:00 [revised]
PHST- 2006/12/15 00:00 [accepted]
PHST- 2007/02/13 09:00 [pubmed]
PHST- 2007/07/21 09:00 [medline]
PHST- 2007/02/13 09:00 [entrez]
AID - S0041-0101(06)00471-5 [pii]
AID - 10.1016/j.toxicon.2006.12.009 [doi]
PST - ppublish
SO  - Toxicon. 2007 May;49(6):855-64. doi: 10.1016/j.toxicon.2006.12.009. Epub 2007 Jan 
      5.