PMID- 17294602
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20071115
IS  - 1827-6806 (Print)
IS  - 1827-6806 (Linking)
VI  - 7
IP  - 12
DP  - 2006 Dec
TI  - [Low-molecular-weight heparins in acute coronary syndrome: acquired results and 
      new perspectives].
PG  - 771-9
AB  - Plaque disruption and thrombosis are the most important pathogenetic mechanisms 
      of acute coronary syndrome (ACS). Although unfractionated heparin (UFH) was the 
      standard antithrombotic agent for the treatment of ACS, low-molecular-weight 
      heparins (LMWH) are an effective alternative antithrombotic therapy for its more 
      favorable pharmacokinetic and pharmacodynamic profile, and several clinical 
      advantages. Some studies have assessed LMWH in comparison with UFH in patients 
      with ACS, but enoxaparin is the only LMWH to have demonstrated significant 
      clinical and economic benefits in this setting of patients. A recent 
      meta-analysis of ESSENCE, TIMI 11B trial, INTERACT, A to Z and SYNERGY studies 
      has shown that enoxaparin is more effective than UFH in preventing the combined 
      endpoint of death or myocardial infarction in ACS without ST-segment elevation. 
      Moreover, the results of ENTIRE-TIMI 23, ASSENT-3 and the recent ExTRACT-TIMI 25 
      have demonstrated that adjunctive antithrombotic therapy with enoxaparin, 
      compared with UFH, reduces the composite endpoint of all-cause mortality or 
      non-fatal reinfarction within 30 days in patients with ST-elevation myocardial 
      infarction who are eligible to receive fibrinolytic therapy.
FAU - Ugo, Fabrizio
AU  - Ugo F
AD  - U.O. di Cardiologia, Dipartimento del Cuore, Azienda Ospedaliero-Universitaria 
      Ospedale Maggiore, Parma. ugo.fabrizio@libero.it
FAU - Ardissino, Diego
AU  - Ardissino D
LA  - ita
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Le eparine a basso peso molecolare nelle sindromi coronariche acute: risultati 
      acquisiti e nuove prospettive.
PL  - Italy
TA  - G Ital Cardiol (Rome)
JT  - Giornale italiano di cardiologia (2006)
JID - 101263411
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
SB  - IM
MH  - Acute Disease
MH  - Algorithms
MH  - Anticoagulants/*therapeutic use
MH  - Coronary Disease/diagnosis/*drug therapy
MH  - Drug Therapy, Combination
MH  - Electrocardiography
MH  - Enoxaparin/*therapeutic use
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - Treatment Outcome
RF  - 34
EDAT- 2007/02/14 09:00
MHDA- 2007/03/21 09:00
CRDT- 2007/02/14 09:00
PHST- 2007/02/14 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2007/02/14 09:00 [entrez]
PST - ppublish
SO  - G Ital Cardiol (Rome). 2006 Dec;7(12):771-9.