PMID- 17295647
OWN - NLM
STAT- MEDLINE
DCOM- 20070405
LR  - 20161124
IS  - 1320-5463 (Print)
IS  - 1320-5463 (Linking)
VI  - 57
IP  - 3
DP  - 2007 Mar
TI  - Bcl2-negative follicular lymphomas frequently have Bcl6 translocation and/or Bcl6 
      or p53 expression.
PG  - 148-52
AB  - Bcl2 is an important protein involved in the pathogenesis of follicular lymphoma 
      (FL). However, approximately 10% of FL cases do not express Bcl2. The present 
      study was designed to compare gene aberrations, prosurvival gene expression, 
      apoptosis and proliferation rates in Bcl2-positive and -negative FL cases. Bcl2 
      translocation and Bcl6 translocation were detected and compared using 
      fluorescence in situ hybridization (FISH). A tendency for Bcl6 translocation to 
      occur was found more frequently in Bcl2-negative FL than in the Bcl2-positive 
      cases. The expression of Bcl-X, BAX, p53, Bcl6 was analyzed by 
      immunohistochemistry. Bcl2 family proteins Bcl-X and BAX were expressed similarly 
      in the two FL types. In some cases of Bcl2-negative FL there was high expression 
      of Bcl6 or p53 but no such Bcl2-positive FL cases were detected. Furthermore, 
      there was an inverse relationship between the expression of Bcl6 and p53. These 
      results indicate that the Bcl6 translocation occurs more frequently in 
      Bcl2-negative FL. Furthermore, other prosurvival proteins such as p53 and Bcl6 
      may play an important role in the pathogenesis of Bcl2-negative FL.
FAU - Guo, Ying
AU  - Guo Y
AD  - Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan.
FAU - Karube, Kennosuke
AU  - Karube K
FAU - Kawano, Riko
AU  - Kawano R
FAU - Suzumiya, Junji
AU  - Suzumiya J
FAU - Takeshita, Morishige
AU  - Takeshita M
FAU - Kikuchi, Masahiro
AU  - Kikuchi M
FAU - Huang, Gao-Sheng
AU  - Huang GS
FAU - Li, Qing
AU  - Li Q
FAU - Ohshima, Koichi
AU  - Ohshima K
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (BCL6 protein, human)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 0 (bcl-2-Associated X Protein)
RN  - 0 (bcl-X Protein)
SB  - IM
MH  - Apoptosis
MH  - Biomarkers, Tumor/metabolism
MH  - Cell Proliferation
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - In Situ Hybridization, Fluorescence
MH  - Lymph Nodes/metabolism/pathology
MH  - Lymphoma, Follicular/*genetics/metabolism/pathology
MH  - Proto-Oncogene Proteins c-bcl-2/*genetics/metabolism
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - *Translocation, Genetic
MH  - Tumor Suppressor Protein p53/*genetics/metabolism
MH  - bcl-2-Associated X Protein/metabolism
MH  - bcl-X Protein/metabolism
EDAT- 2007/02/14 09:00
MHDA- 2007/04/06 09:00
CRDT- 2007/02/14 09:00
PHST- 2007/02/14 09:00 [pubmed]
PHST- 2007/04/06 09:00 [medline]
PHST- 2007/02/14 09:00 [entrez]
AID - PIN2072 [pii]
AID - 10.1111/j.1440-1827.2006.02072.x [doi]
PST - ppublish
SO  - Pathol Int. 2007 Mar;57(3):148-52. doi: 10.1111/j.1440-1827.2006.02072.x.