PMID- 17297482
OWN - NLM
STAT- MEDLINE
DCOM- 20090121
LR  - 20070614
IS  - 1748-7838 (Electronic)
IS  - 1001-0602 (Linking)
VI  - 17
IP  - 6
DP  - 2007 Jun
TI  - Interaction between antigen presenting cells and autoreactive T cells derived 
      from BXSB mice with murine lupus.
PG  - 556-64
AB  - Systemic lupus erythematosus (SLE) is a typical autoimmune disease involving 
      multiple systems and organs. Ample evidence suggests that autoreactive T cells 
      play a pivotal role in the development of this autoimmune disorder. This study 
      was undertaken to investigate the mechanisms of interaction between antigen 
      presenting cells (APCs) and an autoreactive T cell (ATL1) clone obtained from 
      lupus-prone BXSB mice. ATL1 cells, either before or after gamma-ray irradiation, 
      were able to activate naive B cells, as determined by B cell proliferation 
      assays. Macrophages from BXSB mice were able to stimulate the proliferation of 
      resting ATL1 cells at a responder/stimulator (R/S) ratio of 1/2.5. Dendritic 
      cells (DCs) were much more powerful stimulators for ATL1 cells on a per cell 
      basis. The T cell stimulating ability of macrophages and B cells, but not DCs, 
      was sensitive to gamma-ray irradiation. Monoclonal antibodies against mouse 
      MHC-II and CD4 were able to block DC-mediated stimulation of ATL1 proliferation, 
      indicating cognate recognition between ATL1 and APCs. Our data suggest that 
      positive feedback loops involving macrophages, B cells and autoreactive T cells 
      may play a pivotal role in keeping the momentum of autoimmune responses leading 
      to autoimmune diseases.
FAU - Yang, Peng
AU  - Yang P
AD  - Department of Immunology, Peking University Health Science Center, Peking 
      University, 38 Xueyuan Rd, Beijing 100083, China.
FAU - Li, Bo
AU  - Li B
FAU - Lv, Ping
AU  - Lv P
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Gao, Xiao-Ming
AU  - Gao XM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cell Res
JT  - Cell research
JID - 9425763
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/*immunology/pathology
MH  - Autoantibodies/biosynthesis
MH  - B-Lymphocytes/immunology/metabolism
MH  - Cell Communication/*immunology
MH  - Clone Cells
MH  - Lupus Erythematosus, Systemic/*immunology/pathology
MH  - Lymphocyte Activation/*immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - T-Lymphocyte Subsets/*immunology/pathology
EDAT- 2007/02/14 09:00
MHDA- 2009/01/22 09:00
CRDT- 2007/02/14 09:00
PHST- 2007/02/14 09:00 [pubmed]
PHST- 2009/01/22 09:00 [medline]
PHST- 2007/02/14 09:00 [entrez]
AID - 7310146 [pii]
AID - 10.1038/sj.cr.7310146 [doi]
PST - ppublish
SO  - Cell Res. 2007 Jun;17(6):556-64. doi: 10.1038/sj.cr.7310146.