PMID- 17298726
OWN - NLM
STAT- MEDLINE
DCOM- 20070416
LR  - 20190917
IS  - 1472-6483 (Print)
IS  - 1472-6483 (Linking)
VI  - 14
IP  - 2
DP  - 2007 Feb
TI  - Preimplantation diagnosis for immunodeficiencies.
PG  - 214-23
AB  - Preimplantation genetic diagnosis (PGD) has become an established procedure for 
      the detection of single gene disorders, and has recently been performed together 
      with human leukocyte antigen (HLA) typing for couples with children affected by 
      genetic disorders that require HLA-identical stem cell transplantation therapy. 
      For these couples, PGD can ensure the birth of an unaffected child, and because 
      HLA-matched stem cell transplantation improves or completely restores the immune 
      system, this child may also serve as a potential stem cell donor for affected 
      siblings. This paper presents the first cumulative experience (18 cycles) of PGD 
      for detection of the following immunodeficiencies: Wiscott-Aldrich syndrome, 
      X-linked hyper-IgM syndrome (HIGM), X-linked hypohidrotic ectodermal dysplasia 
      with immune deficiency (HED-ID), ataxia telangiectasia and Omenn syndrome, 
      resulting in the transfer of unaffected embryos in 13 cycles and the birth of 
      seven unaffected children, with one healthy pregnancy ongoing. HLA-identical stem 
      cells from some of these children have been used for transplantation therapy, 
      resulting in the restoration of normal function in siblings with HIGM and HED-ID.
FAU - Verlinsky, Yury
AU  - Verlinsky Y
AD  - Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, 
      USA.
FAU - Rechitsky, Svetlana
AU  - Rechitsky S
FAU - Sharapova, Tatyana
AU  - Sharapova T
FAU - Laziuk, Katya
AU  - Laziuk K
FAU - Barsky, Irina
AU  - Barsky I
FAU - Verlinsky, Oleg
AU  - Verlinsky O
FAU - Tur-Kaspa, Ilan
AU  - Tur-Kaspa I
FAU - Kuliev, Anver
AU  - Kuliev A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Embryo, Mammalian/*immunology
MH  - Female
MH  - HLA Antigens
MH  - *Histocompatibility Testing/methods
MH  - Humans
MH  - Immunologic Deficiency Syndromes/*diagnosis
MH  - Pregnancy
MH  - *Preimplantation Diagnosis
EDAT- 2007/02/15 09:00
MHDA- 2007/04/17 09:00
CRDT- 2007/02/15 09:00
PHST- 2007/02/15 09:00 [pubmed]
PHST- 2007/04/17 09:00 [medline]
PHST- 2007/02/15 09:00 [entrez]
AID - S1472-6483(10)60790-0 [pii]
AID - 10.1016/s1472-6483(10)60790-0 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2007 Feb;14(2):214-23. doi: 10.1016/s1472-6483(10)60790-0.