PMID- 17298973
OWN - NLM
STAT- MEDLINE
DCOM- 20071109
LR  - 20220311
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 28
IP  - 13
DP  - 2007 Jul
TI  - Early and sustained effects of cardiac resynchronization therapy on N-terminal 
      pro-B-type natriuretic peptide in patients with moderate to severe heart failure 
      and cardiac dyssynchrony.
PG  - 1592-7
AB  - AIMS: The Cardiac Resynchronization-Heart Failure (CARE-HF) study demonstrated 
      that cardiac resynchronization therapy (CRT) could reduce morbidity and mortality 
      and improve cardiac function in patients with moderate or severe heart failure 
      secondary to left ventricular systolic dysfunction and markers of cardiac 
      dyssynchrony. The purpose of this analysis was to investigate the effect of CRT 
      on plasma concentrations of N-terminal pro-brain natriuretic peptide 
      (NT-pro-BNP), a powerful marker of cardiac dysfunction and prognosis. METHODS AND 
      RESULTS: Blood samples were collected routinely at baseline and 3 and 18 months. 
      Plasma was separated by cool centrifugation and stored at -70 degrees C until 
      transported to a central laboratory for analysis of NT-pro-BNP using a standard 
      commercial assay. Cardiac function was assessed echocardiographically. At 
      baseline, median plasma concentration of NT-pro-BNP was similar in patients 
      assigned to CRT or medical therapy [1920 pg/mL (inter-quartile range (IQR) 
      744-4288) and 1809 pg/mL (IQR 719-3949), respectively]. The differences in 
      medians between the CRT and medical therapy groups were highly significant at 
      both 3 months (537 pg/mL; P < 0.0001) and 18 months of follow-up (567 pg/mL; P < 
      0.0001). These differences could not be accounted for by changes in 
      pharmacological therapy or renal function but were associated with improvement in 
      ventricular volumes and function. CONCLUSION: CRT exerts an early and sustained 
      reduction in NT-pro-BNP. This appears to reflect improvements in ventricular 
      function. NT-pro-BNP may be a simple method for monitoring the effects of CRT.
FAU - Fruhwald, Friedrich M
AU  - Fruhwald FM
AD  - Division of Cardiology, Department of Internal Medicine, Medical University Graz, 
      Auenbruggerplatz 15, 8036 Graz, Austria. freidrich.fruhwald@meduni-graz.at
FAU - Fahrleitner-Pammer, Astrid
AU  - Fahrleitner-Pammer A
FAU - Berger, Rudolf
AU  - Berger R
FAU - Leyva, Francisco
AU  - Leyva F
FAU - Freemantle, Nick
AU  - Freemantle N
FAU - Erdmann, Erland
AU  - Erdmann E
FAU - Gras, Daniel
AU  - Gras D
FAU - Kappenberger, Lukas
AU  - Kappenberger L
FAU - Tavazzi, Luigi
AU  - Tavazzi L
FAU - Daubert, Jean-Claude
AU  - Daubert JC
FAU - Cleland, John G F
AU  - Cleland JG
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20070213
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
CIN - Eur Heart J. 2007 Jul;28(13):1541-2. PMID: 17526506
MH  - Aged
MH  - Arrhythmias, Cardiac/blood/complications/*therapy
MH  - Cardiac Pacing, Artificial/*methods
MH  - Female
MH  - Heart Failure/blood/complications/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*metabolism
MH  - Peptide Fragments/*metabolism
MH  - Ventricular Dysfunction, Left/blood/complications/*therapy
EDAT- 2007/02/15 09:00
MHDA- 2007/11/10 09:00
CRDT- 2007/02/15 09:00
PHST- 2007/02/15 09:00 [pubmed]
PHST- 2007/11/10 09:00 [medline]
PHST- 2007/02/15 09:00 [entrez]
AID - ehl505 [pii]
AID - 10.1093/eurheartj/ehl505 [doi]
PST - ppublish
SO  - Eur Heart J. 2007 Jul;28(13):1592-7. doi: 10.1093/eurheartj/ehl505. Epub 2007 Feb 
      13.